Degenerative and vascular cognitive discorders


This team, made up of clinical and pre-clinical researchers, is multidisciplinary. It is located at the interface between neurology, pharmacology and imaging. The research project is focused on the translational, transnosographic and multimodal study of cognitive disorders associated with degenerative processes or neurovascular lesions, starting from the observation that the mechanisms are entangled.



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Associate Professors/Professors – University-Associated

Pr Régis Bordet
MD, Ph.D., Hospital Practitioner.
University of Lille, Faculty of Medicine.

Pr. Etienne Allard, PH
Dr. Michèle Bastide,  MCF
Dr. Karim Belarbi,  MCF
Pr. Vincent Berezowski,  PR
Dr. Maxime Bertoux,  CR Inserm
Dr. Nacim Betrouni,  CR Inserm
Dr. Muriel Boucart,  DR CNRS
Pr. Yaohua Chen,  PH
Pr. Charlotte Cordonnier,  PU-PH
Pr. Luc Defebvre,  PU-PH
Dr. Stéphanie Bombois, PH
Dr. Julie Deguil,  MCF
Dr.Xavier Delbeucke, MD.
Pr. Christine Delmaire,  PH
Pr. Arnaud Delval,  PU-PH
Pr. Dominique Deplanque,  PU-PH
Pr. Philippe Derambure,  MD, PU-PH
Dr. Jean-Christophe Devedjian, MCF

Pr. David Devos, PU-PH

Pr. Kathy Dujardin, PR
Pr. Patrick Duriez,  PR
Dr. Sophie Gautier,  MCU-PH
Pr. Ilde Hénon,  PH
Dr. Grégory Kuchcinski  MCU-PH
Pr. Xavier Leclerc,  PU-PH

Dr. Quentin Lenoble,  MCF

Pr. Didier Leys,   PU-PH
Pr. Marie-Anne Mackowiak,   PH
Pr. Thomas Modine,  PH
Pr. Christelle Monaca,  PU-PH
Dr. Caroline Moreau,  PU-PH
Dr. Thavarak Ouk,   MCU-PH
Pr. Olivier Outteryck,  PH
Pr. Florence Pasquier,  PU-PH
Dr. Olivier Petrault,  MCF
Pr. Jean-Pierre Pruvo,  PU-PH
Pr. Jean-François Rouland,  PU-PH
Pr. Franck Semah,  PU-PH
Pr. Céline Tard,  PH
Pr. Thi Ha Chau Tran,  PH

Research support staff

Anne-Marie Bordet,  ARC, CHU Lille
Laetitia Breuilh,  ARC, CHU Lille
Marion Buchet,  Admin, CHU Lille
Thibaut Dondaine, IH, CHU Lille
Flore Gouel, IH, CHU Lille
Aurélie Jonneaux, ITA, CHU Lille
Charlotte Laloux,  IR, ULille
Renaud Lopes, IH, CHU Lille
Maud Pétrault, AI, ULille
Elodie Ringot, Admin, CHU Lille
Valerie Santraine, ARC, CHU Lille
Christian Sueur, AJT, ULille
Kelly Timmerman,  AI, CDD
Romain Viard, IH, CDD
Aude Warniez, IR, ULille


Dr. Romain Barus, PharmD. PhD
Dr. Sandrine Bergeron, PharmD. PhD
Dr. Cécile Bordier, PhD

Dr. François Quesque, PhD

Dr. Anne-Sophie Rolland, PhD

Doctoral students

Valentin Bachet

Marie-Amandine Bonte

Hind Bouchaoui

Martin Bretzner

Guillaume Carey

Louise Carton

Jean-Baptiste Davion

Véronique De Conto

Delila Liling

Quentin Devignes

Chirine El Katrib

Clémentine Garric


Morgan Gautherot


Sabine Krohn

Laura Mahoney Sanchez


Sandra Mouchref

Marco Pasi

Laurent Puy

Quentin Vannod

Laurent Zikos

Scientific and medical context

The general scientific objective of the team is to contribute to the societal challenge of cognitive disorders, linked to neurological and mental illnesses. Indeed, the number of people with cognitive decline will double in the next 25 years, due to the increase in life expectancy. This significant increase in the prevalence of cognitive disorders is certainly linked to Alzheimer's disease (AD) but also to neurovascular pathologies and other neurodegenerative pathologies. Vascular and metabolic risk factors themselves contribute to the emergence of cognitive disorders, either directly or through their role in the constitution of silent brain lesions or their interaction with the pathophysiology of neurodegenerative or neurovascular diseases. The societal, family and medico-economic consequences will be significant, leading some to speak of a "tsunami of health care".


An original positioning at the clinical-imaging-pharmacology interface

This field is complex due to the intricacies and requires a multidisciplinary approach, which the team brings given its composition and the results it has already generated on the interactions between degenerative lesions and vascular lesions, on those between cognitive and psychobehavioral signs (especially motor and emotional), on the pathophysiological role of ferroptosis or dysconnectivity, and on the advances in pharmacological development, both symptomatic and 'disease-modifying. The aim is to propose, by an original approach combining clinical-imaging-pharmacology :


  1. a new model for the organization of the management of cognitive disorders, free from the current nosographic frameworks by identifying common physiopathological processes;
  2. a use of biomarkers and algorithms for a better diagnostic typology and an optimization of pharmacological development;
  3. inclusion in the field of human and social sciences by reflecting on what these cognitive disorders represent at the individual and social levels.

A multimodal and multidisciplinary approach :

 To meet the general scientific objective and its medical or social purposes, the project will be broken down into three axes, with for each axis specific questions developed by project-teams and a multimodal methodological approach:


  1. pre-clinical and clinical modeling of degenerative and vascular cognitive disorders;
  2. the study of the pathophysiological bases of degenerative and vascular cognitive   disorders;
  3. the development of innovative pharmacological strategies.



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