Degenerative and vascular cognitive discorders


This team, made up of clinical and pre-clinical researchers, is multidisciplinary. It is located at the interface between neurology, pharmacology and imaging. The research project is focused on the translational, transnosographic and multimodal study of cognitive disorders associated with degenerative processes or neurovascular lesions, starting from the observation that the mechanisms are entangled.


Professor David Devos’ team receives the Etoile Nordiste trophy in the “Science and research” category, for the development of a small internal pump that directly injects dopamine into the brain, thus limiting the heavy side effects of conventional drugs for the treatment of Parkinson’s. Read the article of the Voix du Nord of April 11, 2023

Professor David Devos receives the “Prix des Etoiles de l’Europe”2022

Discover the Pulse protocol


A new neuroprotection biotherapy: the prematuration project.



Associate Professors/Professors – University-Associated

Pr. David Devos, MD. PhD
Professor of Medical pharmacology, neurologist


Pr Régis Bordet
MD, Ph.D., Hospital Practitioner.
University of Lille, Faculty of Medicine.

Pr. Etienne Allard, PH
Dr. Michèle Bastide,  MCF
Dr. Karim Belarbi,  MCF
Pr. Vincent Berezowski,  PR
Dr. Maxime Bertoux,  CR Inserm

Dr. Nacim Betrouni,CR Inserm

Dr. Muriel Boucart,  DR CNRS
Pr. Yaohua Chen,  PH
Pr. Charlotte Cordonnier,  PU-PH
Pr. Luc Defebvre,  PU-PH
Dr. Stéphanie Bombois, PH
Dr. Julie Deguil,  MCF
Dr.Xavier Delbeucke, MD.
Pr. Arnaud Delval,  PU-PH
Pr. Dominique Deplanque,  PU-PH
Pr. Philippe Derambure,  MD, PU-PH
Dr. Jean-Christophe Devedjian, MCF
Thibaut Dondaine, IH, CHU Lille
Pr. Kathy Dujardin, PR
Pr. Patrick Duriez,  PR
Dr. Sophie Gautier,  MCU-PH
Pr. Ilde Hénon,  PH
Dr. Sabine Krohn Bayen, MD
Dr. Grégory Kuchcinski  MCU-PH
Pr. Xavier Leclerc,  PU-PH

Dr. Quentin Lenoble,  MCF

Pr. Didier Leys,   PU-PH
Dr. Marie-Anne Mackowiak, PH
Pr. Thomas Modine,  PH
Pr. Christelle Monaca,  PU-PH

Dr. Caroline Moreau,  PU-PH
Axial symptoms  : biomarkers for neurodegenerative diseases

Dr. Thavarak Ouk,   MCU-PH
Pr. Olivier Outteryck,  PH
Pr. Florence Pasquier,  PU-PH
Dr. Olivier Petrault,  MCF
Dr. Marie Pleuvret,  ARC
Pr. Jean-Pierre Pruvo,  PU-PH
Pr. Jean-François Rouland,  PU-PH
Pr. Franck Semah,  PU-PH
Pr. Céline Tard,  PH
Pr. Thi Ha Chau Tran,  PH
Pr TRAN Thi Mai, PU

European Project Coordinators


Pauline Guyon, legal expert
Clinical project manager


Dr. Anne-Sophie Rolland, PhD,
Clinical and scientific project manager

Research support staff

Anne-Marie Bordet,  ARC, CHU Lille
Laetitia Breuilh,  ARC, CHU Lille
Marion Buchet,  Admin, CHU Lille

Flore Gouel, IH, CHU Lille

Aurélie Jonneaux, ITA, CHU Lille
Charlotte Laloux,  IR, ULille
Patrick Gele,  IR, ULille
Renaud Lopes, IH, CHU Lille
Maud Pétrault, IE, ULille
Elodie Ringot, Admin, CHU Lille
Valerie Santraine, ARC, CHU Lille
Christian Sueur, AJT, ULille
Kelly Timmerman,  AI, CDD

Romain Viard, IH, CDD
Post-processing of MRI images acquired on the LIIFE platform (Lille Invivo Imaging and Functional Exploration)

Aude Warniez, IR, ULille


Dr. Romain Barus, PharmD. PhD
Dr. Sandrine Bergeron, PharmD. PhD
Dr. Cécile Bordier, PhD

Dr. François Quesque, PhD

Doctoral students

Valentin Bachet

Marie-Amandine Bonte

Hind Bouchaoui

Martin Bretzner

Guillaume Carey

Louise Carton

Jean-Baptiste Davion

Véronique De Conto

Delila Liling

Quentin Devignes

Chirine El Katrib

Clémentine Garric

Morgan Gautherot

Sabine Krohn

Laura Mahoney Sanchez

Sandra Mouchref

Marco Pasi

Laurent Puy

Florine Ruthmann

Quentin Vannod

Laurent Zikos

Aurore DUBOS

Scientific and medical context

The general scientific objective of the team is to contribute to the societal challenge of cognitive disorders, linked to neurological and mental illnesses. Indeed, the number of people with cognitive decline will double in the next 25 years, due to the increase in life expectancy. This significant increase in the prevalence of cognitive disorders is certainly linked to Alzheimer's disease (AD) but also to neurovascular pathologies and other neurodegenerative pathologies. Vascular and metabolic risk factors themselves contribute to the emergence of cognitive disorders, either directly or through their role in the constitution of silent brain lesions or their interaction with the pathophysiology of neurodegenerative or neurovascular diseases. The societal, family and medico-economic consequences will be significant, leading some to speak of a "tsunami of health care".


An original positioning at the clinical-imaging-pharmacology interface

This field is complex due to the intricacies and requires a multidisciplinary approach, which the team brings given its composition and the results it has already generated on the interactions between degenerative lesions and vascular lesions, on those between cognitive and psychobehavioral signs (especially motor and emotional), on the pathophysiological role of ferroptosis or dysconnectivity, and on the advances in pharmacological development, both symptomatic and 'disease-modifying. The aim is to propose, by an original approach combining clinical-imaging-pharmacology :


  1. a new model for the organization of the management of cognitive disorders, free from the current nosographic frameworks by identifying common physiopathological processes;
  2. a use of biomarkers and algorithms for a better diagnostic typology and an optimization of pharmacological development;
  3. inclusion in the field of human and social sciences by reflecting on what these cognitive disorders represent at the individual and social levels.

A multimodal and multidisciplinary approach :

 To meet the general scientific objective and its medical or social purposes, the project will be broken down into three axes, with for each axis specific questions developed by project-teams and a multimodal methodological approach:


  1. pre-clinical and clinical modeling of degenerative and vascular cognitive disorders;
  2. the study of the pathophysiological bases of degenerative and vascular cognitive   disorders;
  3. the development of innovative pharmacological strategies.



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