Degenerative and vascular cognitive discorders


This team, made up of clinical and pre-clinical researchers, is multidisciplinary. It is located at the interface between neurology, pharmacology and imaging. The research project is focused on the translational, transnosographic and multimodal study of cognitive disorders associated with degenerative processes or neurovascular lesions, starting from the observation that the mechanisms are entangled.




Pr Régis Bordet
MD, Ph.D., Hospital Biologist.
University of Lille, Faculty of Medicine.

The number of people with cognitive decline will double in the next 25 years, due to increased life expectancy. This significant increase in the prevalence of cognitive disorders is linked to Alzheimer's disease {AD} but also to neurovascular pathologies and other neurodegenerative pathologies.

Faced with this societal challenge, the aim is to offer:

  • a new organizational model for the management of cognitive disorders freed from current nosographic frameworks by identifying common pathophysiological processes.

  • use of biomarkers and algorithms for better nosographic typology and optimization of pharmacological development.

  • a reflection on what these cognitive disorders represent at the individual and social level.

To meet these objectives, the project will be divided into three axes:

A. Pre-clinical and clinical modeling
B. The study of the physiopathological bases
C. The development of innovative pharmacological strategies





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Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, Kilpert F, Franke A, Kiddle S, Sattlecker M, Dobson R, Cuadrado A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Ten Kate M, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Rasmussen KL, Nordestgaard BG, Frikke-Schmidt R, Nielsen SF, Soininen H, Vellas B, Kloszewska I, Mecocci P, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Bertram L, Nevado-Holgado AJ,Lovestone S. Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. J Alzheimers Dis. 2020;77(3):1353-1368. doi: 10.3233/JAD-200208. PMID: 32831200.

Ba K, Casolla B, Caparros F, Bricout N, Della Schiava L, Pasi M, Dequatre-Ponchelle N, Bodenant M, Bordet R, Cordonnier C, Hénon H, Leys D. Early epileptic seizures in ischaemic stroke treated by mechanical thrombectomy:influence of rt-PA. J Neurol. 2020 Aug 14. doi: 10.1007/s00415-020-10155-4. Epub ahead of print. PMID: 32797298.

Lombardo D, Cassé-Perrot C, Ranjeva JP, Le Troter A, Guye M, Wirsich J, Payoux P, Bartrés-Faz D, Bordet R, Richardson JC, Felician O, Jirsa V, Blin O, Didic M, Battaglia D. Modular slowing of resting-state dynamic functional connectivity as a marker of cognitive dysfunction induced by sleep deprivation. Neuroimage. 2020 Jul 29;222:117155. doi: 10.1016/j.neuroimage.2020.117155. Epub ahead of print. PMID: 32736002.

Bordet R, Deplanque D. Brain-liver axis: a new pathway for cognitive disorders related to hepatic fibrosis. Eur J Neurol. 2020 Jul 28. doi: 10.1111/ene.14454. Epub ahead of print. PMID: 32725648.

Tang EYH, Price CI, Robinson L, Exley C, Desmond DW, Köhler S, Staals J, Yin Ka Lam B, Wong A, Mok V, Bordet R, Bordet AM, Dondaine T, Lo JW, Sachdev PS, Stephan BCM; STROKOG Collaboration. Assessing the Predictive Validity of Simple Dementia Risk Models in Harmonized Stroke Cohorts. Stroke. 2020 Jul;51(7):2095-2102. doi: 10.1161/STROKEAHA.120.027473. Epub 2020 Jun 17. PMID:32568644; PMCID: PMC7306263.

Bordet R. Is the drug a scientific, social or political object? Therapie. 2020 Jul-Aug;75(4):389-391. doi: 10.1016/j.therap.2020.05.012. Epub 2020 May 23. PMID: 32482295; PMCID: PMC7244431.

Barus R, Bergeron S, Auger F, Laloux C, Skrobala E, Bongiovanni A, Potey C, Bordet R, Chen Y, Gautier S. Sex Differences in Cognitive Impairment Induced by Cerebral Microhemorrhage. Transl Stroke Res. 2020 May 21. doi:10.1007/s12975-020-00820-1. Epub ahead of print. PMID: 32440818.

Quattrini G, Pievani M, Jovicich J, Aiello M, Bargalló N, Barkhof F, Bartres-Faz D, Beltramello A, Pizzini FB, Blin O, Bordet R, Caulo M, Constantinides M, Didic M, Drevelegas A, Ferretti A, Fiedler U, Floridi P, Gros-Dagnac H, Hensch T, Hoffmann KT, Kuijer JP, Lopes R, Marra C, Müller BW, NobiliF, Parnetti L, Payoux P, Picco A, Ranjeva JP, Roccatagliata L, Rossini PM, Salvatore M, Schonknecht P, Schott BH, Sein J, Soricelli A, Tarducci R, TsolakiM, Visser PJ, Wiltfang J, Richardson JC, Frisoni GB, Marizzoni M; PharmaCog Consortium. Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors. Neuroimage. 2020 Sep;218:116932. doi: 10.1016/j.neuroimage.2020.116932. Epub 2020 May 13. PMID: 32416226.

Lo JW, Crawford JD, Samaras K, Desmond DW, Köhler S, Staals J, Verhey FRJ, Bae HJ, Lee KJ, Kim BJ, Bordet R, Cordonnier C, Dondaine T, Mendyk AM, Lee BC, Yu KH, Lim JS, Kandiah N, Chander RJ, Yatawara C, Lipnicki DM, Sachdev PS; STROKOG Collaboration*. Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study. Stroke. 2020 Jun;51(6):1640-1646. doi: 10.1161/STROKEAHA.119.028428. Epub 2020 May 14. PMID:32404039.

Larrouquere L, Gabin M, Poingt E, Mouffak A, Hlavaty A, Lepelley M, Khouri C, Bellier A, Alexandre J, Bedouch P, Bertoletti L, Bordet R, Bouhanick B, Jonville-Bera AP, Laporte S, Le Jeunne C, Letinier L, Micallef J, Naudet F, Roustit M, Molimard M, Richard V, Cracowski JL. Genesis of an emergency public drug information website by the French Society of Pharmacology and Therapeutics during the COVID-19 pandemic. Fundam Clin Pharmacol. 2020 Jun;34(3):389-396. doi: 10.1111/fcp.12564. PMID: 32394481; PMCID: PMC7273039.

Chan Kwong A, Cassé-Perrot C, Costes-Salon MC, Jouve E, Lanteaume L, Audebert C, Rouby F, Lefebvre MN, Ranjeva JP, Beck A, Deplanque D, Ponchel A, Vervueren C, Truillet R, Babilon C, Auffret A, Richardson JC, Payoux P, Bartrés-Faz D, Blin O, Bordet R, Micallef J; Pharmacog Consortium. An Alzheimer Disease Challenge Model: 24-Hour Sleep Deprivation in Healthy Volunteers, Impact on Working Memory, and Reversal Effect of Pharmacological Intervention: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. J Clin Psychopharmacol. 2020 May/Jun;40(3):222-230. doi: 10.1097/JCP.0000000000001199. PMID: 32332458.

Moreau C, Rolland AS, Pioli E, Li Q, Odou P, Barthelemy C, Lannoy D, Demailly A, Carta N, Deramecourt V, Auger F, Kuchcinski G, Laloux C, Defebvre L, Bordet R, Duce J, Devedjian JC, Bezard E, Fisichella M, Devos D. Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease. Neurobiol Dis. 2020 Jun;139:104846. doi:10.1016/j.nbd.2020.104846. Epub 2020 Mar 20. PMID: 32205254.

Maestrini I, Tagzirt M, Gautier S, Dupont A, Mendyk AM, Susen S, Tailleux A, Vallez E, Staels B, Cordonnier C, Leys D, Bordet R. Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study. Neurology. 2020 Jul 7;95(1):e97-e108. doi: 10.1212/WNL.0000000000009179. Epub 2020 Feb 28. PMID:32111692.

French Association of Addictovigilance Centres, Micallef J, Mallaret M, Lapeyre-Mestre M, Daveluy A, Victorri-Vigneau C, Peyrière H, Debruyne D, DeheulS, Bordet R, Chevallier C, Perault-Pochat MC, Le Boisselier R, Libert F, Chaouachi L, Gillet P. Warning on increased serious health complications related to non-medical use of nitrous oxide. Therapie. 2020 Jan 17:S0040-5957(20)30005-6. French. doi: 10.1016/j.therap.2020.01.002. Epub ahead of print. PMID: 32063400.

Marizzoni M, Ferrari C, Babiloni C, Albani D, Barkhof F, Cavaliere L, Didic M, Forloni G, Fusco F, Galluzzi S, Hensch T, Jovicich J, Marra C, Molinuevo JL, Nobili F, Parnetti L, Payoux P, Ranjeva JP, Ribaldi F, Rolandi E, Rossini PM, Salvatore M, Soricelli A, Tsolaki M, Visser PJ, Wiltfang J, Richardson JC, Bordet R, Blin O, Frisoni GB. CSF cutoffs for MCI due to AD depend on APOEε4 carrier status. Neurobiol Aging. 2020 May;89:55-62. doi: 10.1016/j.neurobiolaging.2019.12.019. Epub 2019 Dec 30. PMID: 32029236.

Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Bertram L, Barkhof F, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Lovestone S. Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. J Alzheimers Dis. 2020;74(1):213-225. doi: 10.3233/JAD-190434. PMID: 31985466; PMCID: PMC7175945.

Stamate D, Kim M, Proitsi P, Westwood S, Baird A, Nevado-Holgado A, Hye A, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, Kate MT, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck E, Engelborghs S, Sleegers K, Bordet R, Ramit L, Kettunen P, Tsolaki M, Verhey F, Alcolea D, Lléo A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Legido-Quigley C. A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimers Dement (N Y). 2019 Dec 18;5:933-938. doi: 10.1016/j.trci.2019.11.001. PMID: 31890857; PMCID:PMC6928349.

Drelon A, Kuchcinski G, Caparros F, Dequatre-Ponchelle N, Moulin S, Cordonnier C, Bordet R, Pruvo JP, Leys D. Remote brain hemorrhage after IV thrombolysis: Role of preexisting lesions. Neurology. 2020 Mar 3;94(9):e961-e967. doi: 10.1212/WNL.0000000000008874. Epub 2019 Dec 27. PMID:31882531.

Lebouvier T, Chen Y, Duriez P, Pasquier F, Bordet R. Antihypertensive agents in Alzheimer's disease: beyond vascular protection. Expert Rev Neurother. 2020 Feb;20(2):175-187. doi: 10.1080/14737175.2020.1708195. Epub 2019 Dec 27. PMID:31869274.

Bordet R, Camu W, De Seze J, Laplaud DA, Ouallet JC, Thouvenot E. Mechanism of action of s1p receptor modulators in multiple sclerosis: The double requirement. Rev Neurol (Paris). 2020 Jan-Feb;176(1-2):100-112. doi:10.1016/j.neurol.2019.02.007. Epub 2019 Nov 19. PMID: 31757428.

Lo JW, Crawford JD, Desmond DW, Godefroy O, Jokinen H, Mahinrad S, Bae HJ, Lim JS, Köhler S, Douven E, Staals J, Chen C, Xu X, Chong EJ, Akinyemi RO, Kalaria RN, Ogunniyi A, Barbay M, Roussel M, Lee BC, Srikanth VK, Moran C, Kandiah N, Chander RJ, Sabayan B, Jukema JW, Melkas S, Erkinjuntti T, Brodaty H, Bordet R, Bombois S, Hénon H, Lipnicki DM, Kochan NA, Sachdev PS; Stroke and Cognition (STROKOG) Collaboration. Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups. Neurology. 2019 Dec 10;93(24):e2257-e2271. doi: 10.1212/WNL.0000000000008612. Epub 2019 Nov 11. PMID: 31712368; PMCID: PMC6937495.

Betrouni N, Yasmina M, Bombois S, Pétrault M, Dondaine T, Lachaud C, Laloux C, Mendyk AM, Henon H, Bordet R. Texture Features of Magnetic Resonance Images: an Early Marker of Post-stroke Cognitive Impairment. Transl Stroke Res. 2020 Aug;11(4):643-652. doi: 10.1007/s12975-019-00746-3. Epub 2019 Nov 1. PMID:31677092.