Degenerative and vascular cognitive discorders

Presentation

This team, made up of clinical and pre-clinical researchers, is multidisciplinary. It is located at the interface between neurology, pharmacology and imaging. The research project is focused on the translational, transnosographic and multimodal study of cognitive disorders associated with degenerative processes or neurovascular lesions, starting from the observation that the mechanisms are entangled.

  • BLOOD, BRAIN AND COGNITION

Project

The massive entry of blood into the brain is a life-threatening event for people of all ages. No specific treatment exists to date. And one third of the survivors experience a decline in their cognitive functions. Even several microscopic hemorrhages no longer appear as silent lesions for the elderly. This project brings together neurologists and scientists to understand the tissue and functional consequences of brain haemorrhages, both macroscopic and microscopic, and to assess the influence of vascular risk factors and anticoagulant treatments. The choice was made of a translational approach combining clinical studies, neuropathological studies, to imaging and innovative experimental models.

Team: Maud PETRAULT, Laurent PUY, Barbara CASOLLA, Olivier PETRAULT, Marco PASI, Michèle BASTIDE, François CAPARROS, Thavarak OUK, Charlotte CORDONNIER, Vincent BEREZOWSKi


Highlights

  • Development of a unique model of disseminated brain microhaemorrhages induced by nanoparticles in mice.
  • Brain microhemorrhages have a proper deleterious effect on cognition in healthy middle-aged mice, but this effect is not aggravated by direct oral anticoagulants or high cholesterol.

  • In humans, NETs (neutrophil extracellular traps) interact with hemostasis in intracerebral hematoma, and neuroinflammation in the perihematomal area.


Publications

Age and diet modify acute microhemorrhage outcome in the mouse brain. Pétrault M, Ouk T, Bastide M, Bordet R, Pétrault O, Bérézowski V. Neurobiol Aging 98 :99-107, 2021.

Safety of oral anticoagulants on experimental brain microbleeding and cognition. Pétrault M, Ouk T, Pétrault O, Bastide M, Bordet R, Bérézowski V. Neuropharmacology. 155:162-172, 2019.

Cerebral microbleeds: Beyond the macroscope. Pétrault M, Casolla B, Ouk T, Cordonnier C, Bérézowski V. Int J Stroke. 14:468-475, 2019.