Development and plasticity of the neuroendocrine brain

Presentation

Located on the campus of the CHU de Lille, the main objective of our laboratory is to decipher the complex dialogue that takes place between the brain and the rest of the body: the role played by the hypothalamus in the control of metabolism and reproduction, and the consequences of a deregulation of this dialogue on the body’s homeostasis, cognitive functions and brain aging. Our laboratory has an international dimension, bringing together the skills of neuroscientists and physicians specialized in reproductive and metabolic disorders and neurosurgery. We work in permanent collaboration with numerous research teams around the world.

@NeuroendoLille

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PRESS

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VIDEO

Health challenge
“The VERTEXA project”.

What if aging well depended on the gateway for hormones to the brain??
Projet WATCH for Well-Aging and the Tanycytic Control of Health.

 

Sensation of satiety: chronicle of Thierry Lhermitte

Vincent Prevot presents his symposium “Hypothalamic tanycytes in metabolic regulation”.

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Principal investigators

LAB DIRECTOR
Dr. Vincent Prévot, Ph.D.
Lead researcher and head of the laboratory.

Vincent Prevot’s research focuses on Systems Neuroscience and Neuroendocrinology, in particular the brain circuits that control reproduction and metabolism and the neural pathways through which they respond to peripheral information.

Dr. Paolo Giacobini, Ph.D.
Principal Investigator & Group Leader.

Expert on developmental neuroscience and neuronal migration.
Paolo Giacobini's research focuses on understanding the neuronal control of reproduction and the molecular mechanisms underlying fertility disorders.

Dr. Sébastien Bouret, Ph.D.
Principal Investigator & Group Leader.

Expert in the neuroendocrinology of obesity. Sebastien's general research interest is to study the role of the perinatal environment and neurodevelopmental mechanisms in lifelong obesity and metabolism.Find out more about Sebastien's work.

Dr Virginie Mattot, Ph.D.
Principal Investigator & Group Leader.

Expertise in : Vascular biology (angiogenesis, endothelial activation, endothelial cell functions and properties) and vascular extracellular matrix.
Ongoing projects: Tissue biophysical properties in the communication between the periphery and the brain: specific roles of blood vessels and extracellular matrix.

Dr. Ariane Sharif, Ph.D.
Principal Researcher & Lecturer.

Ariane’s Research focuses on the importance of glial cells in regulating neuroendocrine processes and targeting therapeutic interventions for glioblastomas.

Dr. Bénédicte Dehouck, Ph.D.
Principal Researcher & Lecturer.

Study of blood-brain interfaces in contributing to the delivery of blood-borne molecules to their neuronal targets.

Dr. Marc Baroncini, M.D, Ph.D.
Principal Researcher & Neurosurgeon (CHRU).

Marc is a neurosurgeon, hospital practitioner at the University Hospital of Lille. He is interested in the anatomy of the hypothalamus, hypothalamic control of metabolism and deregulation in eating disorders. He is also involved in the surgical pathology of cerebrospinal fluid.

Dr Vincent Florent, M.D, Ph.D.
PH in nutrition (CH Arras)

Vincent is a hospital physician specializing in clinical nutrition, metabolism and eating disorders. He is conducting several translational studies including the study of the communication of the hypothalamus with the periphery in humans. He has designed an innovative virtual reality therapeutic game program called VERTEXA, aimed at treating eating disorders.

Scientific coordinators of European projects

Dr. Konstantina Chachlaki, Ph.D.

Contract Researcher; miniNO project

Dr. Sowmyalakshmi Rasika, Ph.D.,

Contract Researcher ; WATCH project

Clinical Partners

Pr. Didier Dewailly, PU-PH, M.D, Ph.D.
Head of Gynaecology, Endocrine and Reproductive Medicine, Professor & Practitioner.
Professeur Emeritus.
Jeanne de Flandre Hospital, (CHU Lille)


Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure.Curriculum Vitæ

Dr. Sophie Catteau-Jonard, PU-PH, M.D, Ph.D.
PU-PH in Reproductive Biology.
Head of Gynecology-Infertility-Medical Assistant for Procreation and Fertility Preservation.
Hôpital Jeanne de Flandre, (CHU Lille).

Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure.

Pr. Claude-Alain Maurage, M.D., Ph.D.
Anatomopathologist, Pathology Dept.
Head of the Institute of Pathology Center of Biology Pathology Genetics,(CHU Lille).

Dr. Anne-Laure Barbotin, M.D, Ph.D.
MCU-PH in Reproductive Biology, (CHU Lille)

Neurostructural hypothalamic plasticity in polycystic ovary syndrome.Formation : Master 2, Paris V University, France.

Engineers

Dr. Cécile Allet, Ph.D.
Research Engineer.
Supervisor: Dr. Paolo Giacobini.

Studies : Doctoral thesis of the University of Lille "Gliogenesis in the hypothalamus during postnatal development: implication in the control of female sexual maturation".
Responsibilities: Responsible for the light microscopy platform of the Center. Responsible for the Center balance park.
Additional training: Sound microscopy, Electron microscopy, Light sheet microscopy, Immunohistochemistry, in situ hybridization, rodent and human brain histology, Animal experimentation.
Publications :
Casoni et al, Development. 2016; 143(21):3969-3981
Delavalle et al, Exp Cell Res. 2011; 317(18):2683-94
Lee-Chang et al, Immunol lett. 2011; 135(1-2):108-17
Prevot et al, Front Neuroendocrinol. 2010; 31(3):241-58
Venna et al, Psychoneuroendocrinology. 2009; 34(2):199-211
Sharif et al, Glia. 2009; 57(4):362-79
Baroncini et al, J Neuroendocrinol. 2007; 19(9):691-702
Sharif et al, Oncogene. 2007; 26(19):2695-706
Sharif et al, Oncogene. 2006: 25(29):4076-85.

Dr. Émilie Caron, Ph.D.
Research Engineer.
Responsible for the murine metabolic phenotyping platform.


Studies:
Doctoral thesis from the University of Lille 2 "Leptin and hypothalamic regulation of reproductive function in mice" 2006. Research master's degree in Neuroscience, University of Lille 2, 2003.
Responsibilities: Maintenance and use of metabolic cages.
Publications :
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG. Mol Metab. 2015, 4(1):15-24.
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175).
Physical activity: benefit or weakness in metabolic adaptations in a mouse model of  chronic food restriction? Méquinion M,  Caron E, Zgheib S, Stievenard A, Zizzari P, Tolle V, Cortet B, Lucas S, Prévot V, Chauveau C, Viltart O. Am J Physiol Endocrinol Metab. 2015 Feb 1;308(3):E241-55.

Sarah Gallet
Study Engineer.
Scientific Supervisor : Dr. Vincent Prévot.

Impact of melatonin hormone on the blood-brain-barrier at the level of the median eminence.

Studies : M.Sc. Biology Biotechnology, University of Lille, 2011.
Responsibilities: Responsible for L2 Cell Culture. Registrar of GMO database.
Additional Training: Animal Experimentation Level I (IV, IP, intracardiac perfusion).
Publications :
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.
Curriculum Vitæ

Assistants Engineers

Danielle Mazur
Assistant Engineer.

Responsibilities: Maintenance and utilization of the cryostats, microtomes etc. Perfusion Room.
Key techniques: Immunohistochemistry, immunofluorescence, electron microscopy.
Publications :
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.

Anne Loyens
Assistant Engineer.

Responsabilités : Electronic microscope. Cell culture room.
Key techniques : Immunohistochemistry, immunofluorescence, in situ hybridization, cell culture, electron microscopy, western blot.
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
De Seranno S, d’Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V. Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence. Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870.

Amandine Legrand
Engineers Assistant.
Gaspard Delpouve
Temporary Engineers Assistant.

Post Docs

Dr. Ines Martinez Corral
Supervisor : Dr. Vincent Prévot.

Dr. Monica Imbernon Ph.D
Supervisor : Dr. Vincent Prévot.
Curriculum VitæSupported by the Marie Sktodowska-Curie action – Research Fellowship Programme

Dr. Daniela Fernandois Ph.D
Supervisor : Dr. Vincent Prévot.

Dr. Sreekala Nampoothiri
Supervisor : Dr. Vincent Prévot.


Dr. Nour El Houda Mimouni
Supervisor: Dr. Paolo Giacobini

Dr. Manon Chasles
Superviseur: Dr. Paolo Giacobini

Dr. Mauro Silva
Supervisor: Dr. Paolo Giacobini

Dr. Ludovica Cotellessa
Supervisor: Dr. Paolo Giacobini

Dr. Marialetizia Rastelli
Superviseur: Dr. Sébastien Bouret

 

Doctoral students

Marion Martin
Supervisor : Dr. Ariane Sharif.Formation : Master 2,  France.

Dr. Maëliss Peigné, M.D
Supervisor : Pr. Sophie Catteau-Jonard.

Tori Lhomme
Supervisor : Dr. Vincent Prévot

Gaetan Ternier
Supervisor: Dr. Paolo Giacobini

Virginia Delli
Supervisor : Dr. Vincent Prévot

Florent Sauvé
Supervisor : Dr. Vincent Prévot

Laura Kuczynski
Supervisor : Dr. Virginie Mattot

Adrian Coutteau Robles
Supervisor : Dr. Ariane Sharif

Eleonora Deligia
Supervisor : Dr. Vincent Prévot

Fatima Timzoura
Supervisor : Dr. Vincent Prévot

Caio Coelho
Supervisor : Dr. Vincent Prévot

Pierre-Yves Barelle
Supervisor : Dr. Sébastien Bouret

Ophélie Hannot
Supervisor : Dr. Bénédicte Dehouck

Laurine Decoster
Supervisor : Dr. Paolo Giacobini

Master students

Alicia Sicardi
Supervisor : Dr. Vincent Prévot

Malia Lasalo
Supervisor : Dr. Vincent Prévot

Nabil Nasri
Supervisor : Dr. Ariane Sharif

Amine Belfoul
Supervisor : Dr. Sébastien Bouret

Alumni

Dr. Manon Duquenne
University of Montreal, Canada


Dr. Sophie Crozier
Group Leader at the UNIL, Lausanne, Switzerland
https://www.unil.ch/cig/en/home/menuinst/research/dr-sophie-croizier.html

Dr. Valerie Leysen

Dr. Charlotte Vanacker,
Post Doctoral Research Fellow, University of Michigan. Moenter Lab, Molecular & Integrative Physiology Department.
Dr. Irène Cimino,
Post Doctoral Research Fellow, University of Cambridge. Yeo Lab, Metabolic Research.
Dr. Mathieu Méquinion,
Post Doctoral Fellow, University of Monash, Zane Lab, Australia.
Dr. Gustav Colldén,
Post Doctoral Research Fellow, German Research Centre for Environmental Health (GmbH). Institute for Diabetes and Obesity. Tschöp Lab.

Dr. Jyoti Parkash,

Assistant Professor Central University of Punjab, Bhatinda, India.

Dr. Andrea Messina,

Research Manager, University Hospital of Lausanne, Switzerland, Pitteloud Lab.

Dr. Filippo Casoni,

Assistant Professor Universita Vita-Salute Sane Raffaele Milan.

Dr. Julien Mallard,
Ph.D Student

Dr. Fanny Langlet,
Group Leader at the UNIL, Lausanne, Switzerland.

Dr. Églantine Balland,
Group Leader at the Monash University, Australia.

Dr. Naresh Hanchate,
Post Doc, Fred Hutchinson Cancer Research Centre, Seattle.

Dr. Nicole Bellefontaine,

Dr. Sophie Steculorum,
Group Leader at the Max Planck Institute for Metabolism Research, Köln, Germany.

Dr. Xavier d’Anglemont de Tassigny,
Miguel Servet Investigator, Instituto de Biomedicina de Sevilla, Seville.

Dr. Amandine Mullier,

Dr. Sara Trova,
Postdoctoral fellow at the Meiji University, Tokyo, Japan

Dr. Giuliana Pellegrino
Scientific and technical Manager at Bordeaux School of Neuroscience, France

Dr. Samuel Malone,
Postdoctoral Research Scientist, Department of Physiology, Anatomy and Genetics, Domingos’ Lab, University of Oxford
Dr. Sonal Shruti,
Upstream Data Coordinator, UCB Pharma, Belgium.
Dr. Jérôme Clasadonte,
Senior Scientist Epilepsy, Team Leader at UCB BioPharma, Belgium.
Dr. Maria Manfredi Lozano,
Postdoctoral Fellow, Instituto de Biomedicina de Sevilla, D’anglemont de Tassigny’s Lab, Spain.
Interactions between hypothalamic neuroendocrine systems and peripheral hormones are increasingly thought to play a fundamental role in postnatal brain development, the impairment of which lies at the origin of several major neurological and psychiatric disorders. In addition, over the last few years, evidence has been accumulating for the involvement of central neurohormone imbalances in both the pathophysiology of cognitive disorders, such as certain early-onset dementias, and in the pathophysiology of metabolic and reproductive disorders such as obesity and infertility. Our laboratory examines how chemotropic factors and peripheral hormones (estrogen, leptin, AMH…) impact hypothalamic development and function, as well as the importance of non-neuronal cells (tanycytes, astrocytes and endothelial cells) in this dialogue between the periphery and the central nervous system.

It also aims to evaluate how pathological conditions (obesity, diabetes etc.) affect these neurobiological events and, conversely, how the impairment of communication between the brain and the periphery renders the organism prone to developing such conditions (obesity, diabetes, precocious and/or delayed puberty and infertility). Our laboratory brings together in a single setting a wide range of theoretical knowledge and technical expertise in its fields of research and is able to investigate physiological and pathological processes from the molecular and genetic/epigenetic levels to that of human patients, thanks to the close interaction between basic scientists and clinicians. For the excellence of our work, our laboratory has been classified as “remarkable” (the highest “grade” attributed to French research laboratories) by our evaluating bodies in 2014 and 2019.

Abbreviations: ARH/me: arcuate nucleus of the hypothalamus/médian eminence; GnRH: gonadotropin releasing hormone; POA: preoptic region; PVH: Periventricular nucleus of the hypothalamus; DMH: dorsomedial nucleus of the hypothalamus; LHA: lateral hypothalamic area; AMH: anti-Mullerian hormone. Our Lab is also actively involved in several Local (FHU 1000 days for Health, DN2M), National (Société de Neuroendocrinologie (SNE), GDR repro, Société des neurosciences (http://www.neurosciences.asso.fr), Club de cellules gliales) and International research networks including LARC-NeurosciencesGnRH network, and FENS.

Original research

2021

Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process.
Mimouni NEH, Paiva I, Barbotin AL, Timzoura FE, Plassard D, Le Gras S, Ternier G, Pigny P, Catteau-Jonard S, Simon V, Prevot V, Boutillier AL, Giacobini P (2021) Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process. Cell Metab DOI: 10.1016/j.cmet.2021.01.004

 

2020

The proportion of cleaved anti-Müllerian hormone is higher in serum but not follicular fluid of obese women independently of polycystic ovary syndrome.
DOI: Peigné M., Pigny1 P., Pankhurst M.W., Drumez E., Loyens A., Dewailly D., Catteau-Jonard S., Giacobini P.
Reproductive BioMedicine Online, 10.1016/j.rbmo.2020.07.020. 

Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.
Messina A, Pulli K, Santini S, Acierno J, Känsäkoski J, Cassatella D, Xu C, Casoni F, Malone SA, Ternier G, Conte D, Sidis Y, Tommiska J, Vaaralahti K, Dwyer A, Gothilf Y, Merlo GR, Santoni F, Niederländer NJ, Giacobini P*, Raivio T*, Pitteloud N*
J. Hum. Genet.DOI:10.1016/j.ajhg.2019.12.003. * Equal contribution.

Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction.
Vanacker C, Trova S, Shruti S, Casoni F, Messina A, Croizier S, Malone S, Ternier G, Hanchate NK, Bouret SG, Ciofi P, Giacobini P, Prevot V
Embo J 2020. 39, e104633

The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates.
Park S, Aintablian A, Coupe B, Bouret SG
Nat Commun 2020. 11, 1914

Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring.
Park S, Jang A, Bouret SG
PLoS Biol 2020. 18, e3000296

Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa.
Florent V, Baroncini M, Jissendi-Tchofo P, Lopes R, Vanhoutte M, Rasika S, Pruvo JP, Vignau J, Verdun S, Johansen JE, Pigeyre M, Bouret SG, Nilsson IAK, Prevot V.
Neuroendocrinology. 2020.  110, 552-562.


2019

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
Van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB, Consortium UK, , Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G. & Farooqi, I.S.
Cell 2019. 176: 729-742 e18

Non-nutritive Sweeteners Induce Hypothalamic ER Stress Causing Abnormal Axon Outgrowth.
Park, S., Sethi, S. & Bouret, S.G.
Front Endocrinol (Lausanne) 2019. 10, 876.

Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism.
Malone, S.A., Papadakis, G.E., Messina, A., Mimouni, N.E.H., Trova, S., Imbernon, M., Allet, C., Cimino, I., Acierno, J., Cassatella, D., Xu, C., Quinton, R., Szinnai, G., Pigny, P., Alonso-Cotchico, L., Masgrau, L., Marechal, J.D., Prevot, V., Pitteloud, N. & Giacobini, P.
Elife 2019. 8: e47198.


2018

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis.
Croizier, S., Park, S., Maillard, J. & Bouret, S.G.
Elife 2018. 7: e40429

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
Tata B, Mimouni NEH, Barbotin AL, Malone SA, Loyens A, Pigny P, Dewailly D, Catteau-Jonard S, Sundström-Poromaa I, Piltonen TT, Dal Bello F, Medana C, Prevot V, Clasadonte J, Giacobini P.
Nat Med. 2018. doi: 10.1038/s41591-018-0035-5.

A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and grey mouse lemur (Microcebus murinus)
Pellegrino G, Trubert C, Terrien J, Pifferi F, Leroy D, Loyens A, Migaud M, Baronicini M, Maurage CA, Fontaine C, Prevot V, Sharif A
J Comp Neurol. 2018. 526(9):1419-1443


2017

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle
Clasadonte, J., E. Scemes, Z. Wang, D. Boison, and P.G. Haydon.
Neuron. 2017.  95:1365-1380.e5.

Phenotyping of nNOS Neurons in the Postnatal and Adult Female Mouse Hypothalamus
Chachlaki K, Malone SA, Qualls-Creekmore, Hrabovszky E, Munzberg H, Giacobini P, Ango F, Prevot V
J Comp Neurol, 2017. 525:3177-3189

Tridimensional Visualization and Analysis of Early Human Development
Belle M, Godefroy D, Couly G, Malone SA, Collier F, Giacobini P, Chedotal A
Cell. 2017. 169:161-173 e112

Reviews

2020

New insights into anti-Müllerian hormone role in the hypothalamic-pituitary-gonadal axis and neuroendocrine development.
Silva MSB, Giacobini P.
Cell Mol Life Sci. 2020. doi: 10.1007/s00018-020-03576-x.

Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.
Stener-Victorin E, Padmanabhan V, Walters KA, Campbell RE, Benrick A, Giacobini P, Dumesic DA, Abbott DH.
Endocr Rev. 2020. 41,538-76.


2019

Nitric oxide signalling in the brain and its control of bodily functions.
Chachlaki K, Prevot V.
Br J Pharmacol. 2019. doi: 10.1111/bph.14800.

Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function.
Barbotin AL, Peigné M, Malone SA, Giacobini P.
Neuroendocrinology. 2019. 109,218-229.

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism.
García-Cáceres C, Balland E, Prevot V, Luquet S, Woods SC, Koch M, Horvath TL, Yi CX, Chowen JA, Verkhratsky A, Araque A, Bechmann I, Tschöp MH.
Nat Neurosci. 2019. 22,7-14.


2018

Wired for eating: how is an active feeding circuitry established in the postnatal brain?
Muscatelli F, Bouret SG.
Curr Opin Neurobiol. 2018. 52, 165-171.

Sex and gender differences in developmental programming of metabolism.
Dearden L, Bouret SG, Ozanne SE.
Mol Metab. 2018.15, 8-19.

The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus
Clasadonte J & Prevot V
Nature Reviews Endocrinology. 2018, 14:25-44.

The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism
Prevot, V., B. Dehouck, A. Sharif, P. Ciofi, P. Giacobini, and J. Clasadonte.
Endocrine Reviews. 2018. doi: 10.1210/er.2017-00235.


2017

The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus
Chachlaki K, Garthwaite J, Prevot V
Nature Reviews Endocrinology. 2017, 13:521-535.

When size matters: how astrocytic processes shape metabolism
Sharif A, Prevot V
Cell Metabolism. 2017, 25:995-996.

General public articles

2018

Rôle des réseaux astrocytaires métaboliques dans le maintien de l’éveil
Clasadonte J
Med Sci (Paris) 2017; 34(3):199-202


2017

Les micro-ARN Nouveaux acteurs du contrôle hypothalamique de la fertilité
Messina A, Langlet F, Prevot V
Med Sci (Paris) 2017; 33:506-511

Tanycytes hypothalamiques, barrière hématoencéphalique et rôle dans la régulation de l’homéostasie énergétique
Florent V, Baroncini M, Prevot V
Cahiers de Nutrition et de Diététique, 52)1):26-32

Développement des neurones à GnRH dans le cerveau d’embryons humains
Barbotin AL, Prevot V, Giacobini P
Medi Sci (Pari) 2017; 33:376-379