Troubles cognitifs dégénératifs et vasculaires

Présentation de l'équipe

Cette équipe composée de chercheurs cliniciens et pré-cliniciens, est pluridisciplinaire. Elle se situe à l’interface entre la neurologie, la pharmacologie et  l’imagerie. Le projet de recherche est centré sur l’étude translationnelle, transnosographique et multimodale des troubles cognitifs associés à des processus dégénératifs ou des lésions neurovasculaires, en partant du constat que les mécanismes en sont intriqués.

À LA UNE

SALLE DE PRESSE

Covid-19
Un test sur smartphone avec résultat quasi-immédiat, conçu à Lille et Marseille

A REGARDER

  • PERSONNEL
  • THÈMES DE RECHERCHE
  • EQUIPES-PROJETS
  • PRODUCTION SCIENTIFIQUE

Chercheurs -Enseignants Chercheurs

Pr Régis Bordet
MD, Ph.D., Praticien Hospitalier.
Université de Lille, Faculté de Médecine.

Pr. Etienne Allard, PH
Dr. Michèle Bastide,  MCF
Dr. Karim Belarbi,  MCF
Pr. Vincent Berezowski,  PR
Dr. Maxime Bertoux,  CR Inserm
Dr. Nacim Betrouni,  CR Inserm
Dr. Muriel Boucart,  DR CNRS
Pr. Yaohua Chen,  PH
Pr. Charlotte Cordonnier,  PU-PH
Pr. Luc Defebvre,  PU-PH
Dr. Stéphanie Bombois, PH
Neurologue
Dr. Julie Deguil,  MCF
Dr.Xavier Delbeucke, MD.
Neuropsychologue
Pr. Christine Delmaire,  PH
Pr. Arnaud Delval,  PU-PH
Pr. Dominique Deplanque,  PU-PH
Pr. Philippe Derambure,  MD, PU-PH
Dr. Jean-Christophe Devedjian, MCF

Pr. David Devos, PU-PH

Pr. Kathy Dujardin, PR
Pr. Patrick Duriez,  PR
Dr. Sophie Gautier,  MCU-PH
Pr. Ilde Hénon,  PH
Dr. Grégory Kuchcinski  MCU-PH
Pr. Xavier Leclerc,  PU-PH

Dr. Quentin Lenoble,  MCF


Pr. Didier Leys,   PU-PH
Pr. Marie-Anne Mackowiak,   PH
Pr. Thomas Modine,  PH
Pr. Christelle Monaca,  PU-PH
Dr. Caroline Moreau,  PU-PH
Dr. Thavarak Ouk,   MCU-PH
Pr. Olivier Outteryck,  PH
Pr. Florence Pasquier,  PU-PH
Dr. Olivier Petrault,  MCF
Pr. Jean-Pierre Pruvo,  PU-PH
Pr. Jean-François Rouland,  PU-PH
Pr. Franck Semah,  PU-PH
Pr. Céline Tard,  PH
Pr. Thi Ha Chau Tran,  PH


Personnels soutien à la recherche

Anne-Marie Bordet,  ARC, CHU Lille
Laetitia Breuilh,  ARC, CHU Lille
Marion Buchet,  Admin, CHU Lille
Thibaut Dondaine, IH, CHU Lille
Flore Gouel, IH, CHU Lille
Aurélie Jonneaux, ITA, CHU Lille
Charlotte Laloux,  IR, ULille
Renaud Lopes, IH, CHU Lille
Maud Pétrault, AI, ULille
Elodie Ringot, Admin, CHU Lille
Valerie Santraine, ARC, CHU Lille
Christian Sueur, AJT, ULille
Kelly Timmerman,  AI, CDD
Romain Viard, IH, CDD
Aude Warniez, IR, ULille


Post-Doctorants

Dr. Romain Barus, PharmD. PhD
Dr. Sandrine Bergeron, PharmD. PhD
Dr. Cécile Bordier, PhD

Dr. François Quesque, PhD

Dr. Anne-Sophie Rolland, PhD


Doctorants

Valentin Bachet

Marie-Amandine Bonte

Hind Bouchaoui

Martin Bretzner

Guillaume Carey

Louise Carton

Jean-Baptiste Davion

Véronique De Conto

Delila Liling

Quentin Devignes

Chirine El Katrib

Clémentine Garric

Morgan Gautherot

Sabine Krohn

Laura Mahoney Sanchez

Sandra Mouchref

Marco Pasi

Laurent Puy

Quentin Vannod

Laurent Zikos

Contexte scientifique et médical


L’objectif scientifique général de l’équipe est de contribuer à répondre au défi sociétal que représentent les troubles cognitifs, liés à des maladies neurologiques et mentales. En effet, le nombre de personnes ayant un déclin cognitif va doubler dans les 25 prochaines années, en raison de l’augmentation de l’espérance de vie. Cette augmentation importante de prévalence des troubles cognitifs est certes liée à la maladie d’Alzheimer (MA) mais aussi aux pathologies neurovasculaires et à d’autres pathologies neurodégénératives. En eux-mêmes, les facteurs de risque vasculaires et métaboliques contribuent à l’émergence de troubles cognitifs, soit directement, soit par leur rôle dans la constitution de lésions cérébrales silencieuses ou leur intrication avec la physiopathologie des maladies neurodégénératives ou neurovasculaires. Les conséquences sociétales, familiales et médico-économiques seront importantes, amenant certains à parler de "tsunami of health care".

Un positionnement original à l’interface clinique-imagerie-pharmacologie


Ce domaine est complexe compte tenu des intrications et nécessite une approche multidisciplinaire, qu’apporte l’équipe compte tenu de sa composition et des résultats qu’elle a déjà pu générer sur les interactions entre lésions dégénératives et lésions vasculaires, sur celles entre signes cognitifs et psychocomportementaux (notamment moteurs et émotionnels), sur le rôle physiopathologique de la ferroptose ou de la dysconnectivité, sur les avancées en matière de développement pharmacologique tant symptomatique que ‘disease-modifier’. La finalité est de proposer :

  1. un nouveau modèle d’organisation de la prise en charge des troubles cognitifs affranchis des cadres nosographiques actuels par l’identification de processus physiopathologiques communs ;

  2. une utilisation de biomarqueurs et d’algorithme pour une meilleure typologie diagnostique et une optimisation du développement pharmacologique ;

  3. une inscription dans le champ des sciences humaines et sociales par une réflexion sur ce que représentent ces troubles cognitifs à l’échelon individuel et social.

Une approche multimodale et multidisciplinaire


Pour répondre à l’objectif scientifique général et à ses finalités médicales ou sociales, le projet sera décliné en trois axes, avec pour chaque axe des questions précises développées par des équipes-projets et une approche méthodologique multimodale :

  1. la modélisation pré-clinique et clinique des troubles cognitifs dégénératifs et vasculaires ;
  2. l’étude des bases physiopathologiques des troubles cognitifs dégénératifs et vasculaires ;
  3. le développement de stratégies pharmacologiques innovantes.

Publications

2021

Delval A, Bayot M, Lapoulvereyrie R, Defebvre L, Vermersch P, Tard C , Role of the peripheral nervous system for an appropriate postural preparation during gait initiation in patients with a chronic inflammatory demyelinating polyneuropathy: A pilot study., Gait Posture, 2021 , 29-35

Péran P, Salabert AS, Dondaine T, Leclerc X, Gros-Dagnac H, Ranjeva JP & al , Functional connectivity and cognitive changes after donepezil treatment in healthy participants., Psychopharmacology (Berl), 2021

Greenberg SM, Cordonnier C, Schneider JA, Smith EE, van Buchem MA, van Veluw SJ & al , Off-label use of aducanumab for cerebral amyloid angiopathy., Lancet Neurol, 2021

Christensen H, Cordonnier C , Age At Menopause: A Female Risk Factor of Stroke?, Stroke, 2021 , STROKEAHA121034828

Wood SN, Karp C, OlaOlorun F, Pierre AZ, Guiella G, Gichangi P & al , Need for and use of contraception by women before and during COVID-19 in four sub-Saharan African geographies: results from population-based national or regional cohort surveys., Lancet Glob Health, 2021 , e793-e801

Vayne C, Rollin J, Gruel Y, Pouplard C, Galinat H, Huet O & al , PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia., N Engl J Med, 2021

Puy L, Corseaux D, Perbet R, Deramecourt V, Cordonnier C, Bérézowski V , Neutrophil Extracellular Traps (NETs) Infiltrate Haematoma And Surrounding Brain Tissue after Intracerebral Haemorrhage: a Post-Mortem Study., Neuropathol Appl Neurobiol, 2021

Leys D, Edwards M, Vonck K, Taba P, Moro E, Chan A & al , SARS-COV2 vaccine-related neurological complications need large collaborative studies, not single case reports or small descriptive series., Eur J Neurol, 2021

Masheka-Cishesa O, Kyheng M, Cordonnier C, Kuchcinski G, Chochoi M, Lejeune JP & al , Seizures after decompressive hemicraniectomy for large middle cerebral artery territory infarcts: incidence, associated factors and impact on long-term outcomes., Eur J Neurol, 2021

Bocchetta M, Todd EG, Peakman G, Cash DM, Convery RS, Russell LL & al , Differential early subcortical involvement in genetic FTD within the GENFI cohort., Neuroimage Clin, 2021 , 102646

Benkebil M, Gautier S, Gras-Champel V, Massy N, Micallef J, Valnet Rabier MB , COVID-19 vaccines surveillance in France: a global response to a major national challenge., Anaesth Crit Care Pain Med, 2021 , 100866

Modine T, Ben-Ali W , How to eliminate mitral regurgitation definitively: the eternal dilemma?, EuroIntervention, 2021 , 1384-1385

Turke S, Nehrling S, Adebayo SO, Akilimali P, Idiodi I, Mwangi A & al , Remote Interviewer Training for COVID-19 Data Collection: Challenges and Lessons Learned From 3 Countries in Sub-Saharan Africa., Glob Health Sci Pract, 2021 , 177-186

Bonte MA, El Idrissi F, Gressier B, Devos D, Belarbi K , Protein network exploration prioritizes targets for modulating neuroinflammation in Parkinson's disease., Int Immunopharmacol, 2021 , 107526

Bonnet C, Blondel B, Moreau C , A rise in births following contraceptive failure in France between 2010 and 2016: results from the French national perinatal surveys, BMC Womens Health, 2021

Niguet JP, Tortuyaux R, Garcia B, Jourdain M, Chaton L, Préau S & al , Neurophysiological findings and their prognostic value in critical COVID-19 patients: An observational study., Clin Neurophysiol, 2021 , 1009-1017

Ternacle J, Ben Ali W, Modine T , Transcatheter Repair for Tricuspid Regurgitation: Ready or Not?, JACC Cardiovasc Interv, 2021 , 584-585

Moonen AJH, Mulders AEP, Defebvre L, Duits A, Flinois B, Köhler S & al , Cognitive Behavioral Therapy for Anxiety in Parkinson's Disease: A Randomized Controlled Trial., Mov Disord, 2021

Outteryck O, Leclerc X , Author Response: Asymptomatic Optic Nerve Lesions: An Underestimated Cause of Silent Retinal Atrophy in MS., Neurology, 2021 , 350-351

Puy L, Pasi M, Rodrigues M, van Veluw SJ, Tsivgoulis G, Shoamanesh A & al , Cerebral microbleeds: from depiction to interpretation., J Neurol Neurosurg Psychiatry, 2021

Bayen S, Carpentier C, Baran J, Cottencin O, Defebvre L, Moreau C & al , Parkinson's disease: Content analysis of patient online discussion forums. A prospective observational study using Netnography., Patient Educ Couns, 2021

Leys D , One year later., Eur J Neurol, 2021

Betrouni N, Moreau C, Rolland AS, Carrière N, Chupin M, Kuchcinski G & al , Texture-based markers from structural imaging correlate with motor handicap in Parkinson's disease., Sci Rep, 2021 , 2724

Bayot M, Delval A, Moreau C, Defebvre L, Hansen C, Maetzler W & al , Initial center of pressure position prior to anticipatory postural adjustments during gait initiation in people with Parkinson's disease with freezing of gait., Parkinsonism Relat Disord, 2021 , 8-14

Bergeron S, Barus R, Leboullenger C, Auger F, Bongiovanni A, Tardivel M & al , Beneficial effects of atorvastatin on sex-specific cognitive impairment induced by a cerebral microhaemorrhage in a murine model., Br J Pharmacol, 2021

Kas A, Soret M, Pyatigoskaya N, Habert MO, Hesters A, Le Guennec L & al , The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study., Eur J Nucl Med Mol Imaging, 2021

Delval A, Betrouni N, Tard C, Devos D, Dujardin K, Defebvre L & al , Do kinematic gait parameters help to discriminate between fallers and non-fallers with Parkinson's disease?, Clin Neurophysiol, 2020 , 536-541

Leys D , A special issue on SARS-CoV-2, Eur. J. Neurol., 2020 , 1709-1709

Leroy M, Bertoux M, Skrobala E, Mode E, Adnet-Bonte C, Le Ber I & al , Characteristics and progression of patients with frontotemporal dementia in a regional memory clinic network., Alzheimers Res Ther, 2021 , 19

Boussac M, Arbus C, Dupouy J, Harroch E, Rousseau V, Croiset A & al , Personality dimensions of patients can change during the course of parkinson's disease., PLoS One, 2021 , e0245142

Aboukais R, Tétard MC, Devalckeneer A, Boussemart P, Bourgeois P, Bricout N & al , Ruptured blood blister like aneurysm: does the best therapeutic option really exist?, Neurosurg Rev, 2021

Lopes R, Bournonville C, Kuchcinski G, Dondaine T, Mendyk AM, Viard R & al , Prediction of Long-term Cognitive Functions after Minor Stroke, Using Functional Connectivity., Neurology, 2021

Lacan L, Betrouni N, Lamblin MD, Chaton L, Delval A, Bourriez JL & al , Quantitative approach to early neonatal EEG visual analysis in hypoxic-ischemic encephalopathy severity: Bridging the gap between eyes and machine., Neurophysiol Clin, 2021

2020

Carey G, Gormezoglu M, de Jong JJA, Hofman PAM, Backes WH, Dujardin K & al , Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review, Mov. Disord., 2020

Pétrault M, Ouk T, Bastide M, Bordet R, Pétrault O, Bérézowski V , Age and diet modify acute microhemorrhage outcome in the mouse brain., Neurobiol Aging, 2020 , 99-107

Delila L, Wu YW, Nebie O, Widyaningrum R, Chou ML, Devos D & al , Extensive characterization of the composition and functional activities of five preparations of human platelet lysates for dedicated clinical uses., Platelets, 2020 , 1-14

Pasi M, Casolla B, Kyheng M, Boulouis G, Kuchcinski G, Moulin S & al , Long-term functional decline of spontaneous intracerebral haemorrhage survivors., J Neurol Neurosurg Psychiatry, 2020

Bertoux M, Duclos H, Caillaud M, Segobin S, Merck C, de La Sayette V & al , When affect overlaps with concept: emotion recognition in semantic variant of primary progressive aphasia., Brain, 2020

Devos D, Hirsch E, Wyse R , Seven Solutions for Neuroprotection in Parkinson's Disease., Mov Disord, 2020

Bayot M, Dujardin K, Dissaux L, Tard C, Defebvre L, Bonnet CT & al , Can dual-task paradigms predict Falls better than single task? - A systematic literature review., Neurophysiol Clin, 2020

Viseux FJF, Delval A, Defebvre L, Simoneau M , Postural instability in Parkinson's disease: Review and bottom-up rehabilitative approaches., Neurophysiol Clin, 2020

Puy L, Cordonnier C , Cerebral Microbleeds and Antithrombotic Treatments-Stop Worrying About Bleeding., JAMA Neurol, 2020

Gaboriau L, Davion JB, Combret S, Lebrun-Vignes B, Rocher F, Rouby F & al , Adalimumab and myositis: A case report and review of the French and international Pharmacovigilance Databases., Neuromuscul Disord, 2020

Belarbi K, Cuvelier E, Bonte MA, Desplanque M, Gressier B, Devos D & al , Glycosphingolipids and neuroinflammation in Parkinson''s disease., Mol Neurodegener, 2020 , 59

Carey G, Lopes R, Viard R, Betrouni N, Kuchcinski G, Devignes Q & al , Anxiety in Parkinson''s disease is associated with changes in the brain fear circuit., Parkinsonism Relat. Disord., 2020 , 89-97

Drunat O, Roche J, Kohler S, Vernaudon J, Saidlitz P, Lenoir H & al , What the COVID pandemic entails for the management of patients with behavioral and psychological symptoms of dementia: experience in France., Int Psychogeriatr, 2020 , 1-7

Modine T, Ibrahim R, Ben-Ali W , Massive or Torrential Tricuspid Regurgitation: The Weight of the Flow!, JACC Cardiovasc Interv, 2020 , 2010-2011

Peuchot J, Allard E, Dureuil B, Veber B, Compère V , Efficiency of Text Message Contact on Medical Safety in Outpatient Surgery: Retrospective Study., JMIR Mhealth Uhealth, 2020 , e14346

Magnat M, Cordonnier C, Leclerc X, Amad A , Effectiveness of electroconvulsive therapy in a patient with radiation-induced brain injuries., Aust N Z J Psychiatry, 2020 , 4867420952535

Ben Hassen W, Tordjman M, Boulouis G, Bretzner M, Bricout N, Legrand L & al , Benefit of First Pass Complete Reperfusion in Thrombectomy is Mediated by Limited Infarct Growth., Eur. J. Neurol., 2020

Pasi M, Casolla B, Kyheng M, Boulouis G, Kuchcinski G, Moulin S & al , Long-term mortality in survivors of spontaneous intracerebral hemorrhage., Int J Stroke, 2020 , 1747493020954946

Ba K, Casolla B, Caparros F, Bricout N, Della Schiava L, Pasi M & al , Early epileptic seizures in ischaemic stroke treated by mechanical thrombectomy: influence of rt-PA., J. Neurol., 2020

Bertoux M, Cassagnaud P, Lebouvier T, Lebert F, Sarazin M, Le Ber I & al , Does amnesia specifically predict Alzheimer''s pathology? A neuropathological study., Neurobiol. Aging, 2020 , 123-130

Basirat A, Schwartz JL, Moreau C , Word segmentation based on prosody in Parkinson''s Disease., Clin Linguist Phon, 2020 , 1-8

Mahoney-Sánchez L, Bouchaoui H, Ayton S, Devos D, Duce JA, Devedjian JC , Ferroptosis and its potential role in the physiopathology of Parkinson''s Disease., Prog. Neurobiol., 2020 , 101890

Bordet R, Deplanque D , Brain-liver axis: a new pathway for cognitive disorders related to hepatic fibrosis., Eur. J. Neurol., 2020

Outteryck O, Lopes R, Drumez É, Labreuche J, Lannoy J, Hadhoum N & al , Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome., Neurology, 2020

Coisne A, Pontana F, Aghezzaf S, Mouton S, Ridon H, Richardson M & al , Utility of Three-Dimensional Transesophageal Echocardiography for Mitral Annular Sizing in Transcatheter Mitral Valve Replacement Procedures: A Cardiac Computed Tomographic Comparative Study., J Am Soc Echocardiogr, 2020

Casolla B, Kuchcinski G, Kyheng M, Hanafi R, Lejeune JP, Leys D & al , Infarct Volume Before Hemicraniectomy in Large Middle Cerebral Artery Infarcts Poorly Predicts Catastrophic Outcome., Stroke, 2020 , STROKEAHA120029920

Kreisler A, Simonin C, Degardin A, Mutez E, Defebvre L , Anatomy-guided injections of botulinum neurotoxin in neck muscles: how accurate is needle placement?, Eur. J. Neurol., 2020

Grolez G, Viard R, Lopes R, Kuchcinski G, Defebvre L, Devos D & al , Functional correlates of cognitive slowing in Parkinson''s disease., Parkinsonism Relat. Disord., 2020 , 3-9

Kaaouana O, Bricout N, Casolla B, Caparros F, Schiava LD, Mounier-Vehier F & al , Mechanical thrombectomy for ischaemic stroke in the anterior circulation: off-hours effect., J. Neurol., 2020

Tsatsanis A, Wong BCX, Gunn AP, Ayton S, Bush AI, Devos D & al , Amyloidogenic processing of Alzheimer''''s disease beta-amyloid precursor protein induces cellular iron retention, Mol. Psychiatr., 2020

Boussac M, Arbus C, Dupouy J, Harroch E, Rousseau V, Ory-Magne F & al , Personality Dimensions Are Associated with Quality of Life in Fluctuating Parkinson''s Disease Patients (PSYCHO-STIM)., J Parkinsons Dis, 2020

Barus R, Bergeron S, Auger F, Laloux C, Skrobala E, Bongiovanni A & al , Sex Differences in Cognitive Impairment Induced by Cerebral Microhemorrhage., Transl Stroke Res, 2020

Thillard EM, Gautier S, Babykina E, Carton L, Amad A, Bouzillé G & al , Psychiatric Adverse Events Associated With Infliximab: A Cohort Study From the French Nationwide Discharge Abstract Database., Front Pharmacol, 2020 , 513

Hodel J, Leclerc X, Zuber M, Gerber S, Besson P, Marcaud V & al , Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia., AJNR Am J Neuroradiol, 2020

Debry N, Trimech TR, Gandet T, Vincent F, Hysi I, Delhaye C & al , Transaxillary compared with transcarotid access for TAVR: a propensity-matched comparison from a French multicenter registry., EuroIntervention, 2020

Pico F, Lapergue B, Ferrigno M, Rosso C, Meseguer E, Chadenat ML & al , Effect of In-Hospital Remote Ischemic Perconditioning on Brain Infarction Growth and Clinical Outcomes in Patients With Acute Ischemic Stroke: The RESCUE BRAIN Randomized Clinical Trial., JAMA Neurol, 2020

Baille G, Chenivesse C, Perez T, Dujardin K, Defebvre L, Moreau C , Dyspnea: A Missing Item of the MDS-UPDRS Part I?, Mov. Disord., 2020

Moreau C, Rolland AS, Pioli E, Li Q, Odou P, Barthelemy C & al , Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson''s disease., Neurobiol. Dis., 2020 , 104846

Pokeerbux MR, Delmaire C, Morell-Dubois S, Demondion X, Lambert M , Styloidogenic compression of the internal jugular vein, a new venous entrapment syndrome?, Vasc Med, 2020 , 1358863X20902842

Casolla B, Kyheng M, Kuchcinski G, Lejeune JP, Hanafi R, Bodenant M & al , Predictors of outcome in 1-month survivors of large middle cerebral artery infarcts treated by decompressive hemicraniectomy., J. Neurol. Neurosurg. Psychiatry, 2020

Maestrini I, Tagzirt M, Gautier S, Dupont A, Mendyk AM, Susen S & al , MPO is partially associated with neutrophil deleterious effect in acute cerebral ischemia., Neurology, 2020

Coisne A, Ninni S, Pontana F, Aghezzaf S, Janvier F, Mouton S & al , Clinical significance of electrocardiographic markers of myocardial damage prior to aortic valve replacement., Int. J. Cardiol., 2020

Dujardin K, Sgambato V , Neuropsychiatric Disorders in Parkinson''s Disease: What Do We Know About the Role of Dopaminergic and Non-dopaminergic Systems?, Front Neurosci, 2020 , 25

Laurent A, Artiges E, Mellerio C, Boutin-Watine M, Landré E, Semah F & al , Metabolic correlates of cognitive impairment in mesial temporal lobe epilepsy., Epilepsy Behav, 2020 , 106948

Leys D , How can neurology be affected by the \"100 Radical Innovation Breakthroughs for the future\" report of the European Commission?, Eur. J. Neurol., 2020

Leclerc X, Guillaud O, Reyns N, Hodel J, Outteryck O, Bala F & al , Follow-Up MRI for Small Brain AVMs Treated by Radiosurgery: Is Gadolinium Really Necessary?, AJNR Am J Neuroradiol, 2020

Bapst B, Amegnizin JL, Vignaud A, Kauv P, Maraval A, Kalsoum E & al , POST-CONTRAST 3D T1-WEIGHTED TSE MR SEQUENCES (SPACE, CUBE, VISTA/BRAINVIEW, isoFSE, 3D MVOX): TECHNICAL ASPECTS AND CLINICAL APPLICATIONS., J Neuroradiol, 2020

Caparros F, Kuchcinski G, Drelon A, Casolla B, Moulin S, Dequatre-Ponchelle N & al , Use of MRI to predict symptomatic haemorrhagic transformation after thrombolysis for cerebral ischaemia., J. Neurol. Neurosurg. Psychiatry, 2020

Ben Ali W, Overtchouk P, Modine T , Do we need alternative access in TAVR anymore?, EuroIntervention, 2020 , e1305-e1306

Derollez C, Haik S, Pasquier F, De Toffol B, Bombois S , Diagnosis of severe cognitive disorder: the family history as a key issue., Neurol. Sci., 2020

Devos D, Cabantchik ZI, Moreau C, Danel V, Mahoney-Sanchez L, Bouchaoui H & al , Conservative iron chelation for neurodegenerative diseases such as Parkinson''s disease and amyotrophic lateral sclerosis., J Neural Transm (Vienna), 2020

Hong S, Prokopenko D, Dobricic V, Kilpert F, Bos I, Vos SJB, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Cleynen I, Gabel S, Schaeverbeke J, Scheltens P, Teunissen CE, Niemantsverdriet E, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Kettunen P, Wallin A, Lleó A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Wittig M, Franke A, Tanzi RE, Visser PJ, Bertram L . Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker. Discovery dataset. Transl Psychiatry. 2020 Nov 22;10(1):403. doi: 10.1038/s41398-020-01074-z. PMID: 33223526.

Ribaldi F, Altomare D, Jovicich J, Ferrari C, Picco A, Pizzini FB, Soricelli A, Mega A, Ferretti A, Drevelegas A, Bosch B, Müller BW, Marra C, Cavaliere C, Bartrés-Faz D, Nobili F, Alessandrini F, Barkhof F, Gros-Dagnac H, Ranjeva JP, Wiltfang J, Kuijer J, Sein J, Hoffmann KT, Roccatagliata L, Parnetti L, Tsolaki M, Constantinidis M, Aiello M, Salvatore M, Montalti M, Caulo M, Didic M, Bargallo N, Blin O, Rossini P, Schonknecht P, Floridi P, Payoux P, Visser PJ,Bordet R, Lopes R, Tarducci R, Bombois S, Hensch T, Fiedler U, Richardson JC, Frisoni GB, Marizzoni M. Accuracy and reproducibility of automated white matter hyperintensities segmentation with lesion segmentation tool: A European multi-site 3T study. Magn Reson Imaging. 2020 Nov 18:S0730-725X(20)30643-3. doi: 10.1016/j.mri.2020.11.008. Epub ahead of print. PMID: 33220450.

Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, Kilpert F, Franke A, Kiddle S, Sattlecker M, Dobson R, Cuadrado A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Ten Kate M, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Rasmussen KL, Nordestgaard BG, Frikke-Schmidt R, Nielsen SF, Soininen H, Vellas B, Kloszewska I, Mecocci P, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Bertram L, Nevado-Holgado AJ,Lovestone S. Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. J Alzheimers Dis. 2020;77(3):1353-1368. doi: 10.3233/JAD-200208. PMID: 32831200.

Ba K, Casolla B, Caparros F, Bricout N, Della Schiava L, Pasi M, Dequatre-Ponchelle N, Bodenant M, Bordet R, Cordonnier C, Hénon H, Leys D. Early epileptic seizures in ischaemic stroke treated by mechanical thrombectomy:influence of rt-PA. J Neurol. 2020 Aug 14. doi: 10.1007/s00415-020-10155-4. Epub ahead of print. PMID: 32797298.

Lombardo D, Cassé-Perrot C, Ranjeva JP, Le Troter A, Guye M, Wirsich J, Payoux P, Bartrés-Faz D, Bordet R, Richardson JC, Felician O, Jirsa V, Blin O, Didic M, Battaglia D. Modular slowing of resting-state dynamic functional connectivity as a marker of cognitive dysfunction induced by sleep deprivation. Neuroimage. 2020 Jul 29;222:117155. doi: 10.1016/j.neuroimage.2020.117155. Epub ahead of print. PMID: 32736002.

Bordet R, Deplanque D. Brain-liver axis: a new pathway for cognitive disorders related to hepatic fibrosis. Eur J Neurol. 2020 Jul 28. doi: 10.1111/ene.14454. Epub ahead of print. PMID: 32725648.

Tang EYH, Price CI, Robinson L, Exley C, Desmond DW, Köhler S, Staals J, Yin Ka Lam B, Wong A, Mok V, Bordet R, Bordet AM, Dondaine T, Lo JW, Sachdev PS, Stephan BCM; STROKOG Collaboration. Assessing the Predictive Validity of Simple Dementia Risk Models in Harmonized Stroke Cohorts. Stroke. 2020 Jul;51(7):2095-2102. doi: 10.1161/STROKEAHA.120.027473. Epub 2020 Jun 17. PMID:32568644; PMCID: PMC7306263.

Bordet R. Is the drug a scientific, social or political object? Therapie. 2020 Jul-Aug;75(4):389-391. doi: 10.1016/j.therap.2020.05.012. Epub 2020 May 23. PMID: 32482295; PMCID: PMC7244431.

Barus R, Bergeron S, Auger F, Laloux C, Skrobala E, Bongiovanni A, Potey C, Bordet R, Chen Y, Gautier S. Sex Differences in Cognitive Impairment Induced by Cerebral Microhemorrhage. Transl Stroke Res. 2020 May 21. doi:10.1007/s12975-020-00820-1. Epub ahead of print. PMID: 32440818.

Quattrini G, Pievani M, Jovicich J, Aiello M, Bargalló N, Barkhof F, Bartres-Faz D, Beltramello A, Pizzini FB, Blin O, Bordet R, Caulo M, Constantinides M, Didic M, Drevelegas A, Ferretti A, Fiedler U, Floridi P, Gros-Dagnac H, Hensch T, Hoffmann KT, Kuijer JP, Lopes R, Marra C, Müller BW, NobiliF, Parnetti L, Payoux P, Picco A, Ranjeva JP, Roccatagliata L, Rossini PM, Salvatore M, Schonknecht P, Schott BH, Sein J, Soricelli A, Tarducci R, TsolakiM, Visser PJ, Wiltfang J, Richardson JC, Frisoni GB, Marizzoni M; PharmaCog Consortium. Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors. Neuroimage. 2020 Sep;218:116932. doi: 10.1016/j.neuroimage.2020.116932. Epub 2020 May 13. PMID: 32416226.

Lo JW, Crawford JD, Samaras K, Desmond DW, Köhler S, Staals J, Verhey FRJ, Bae HJ, Lee KJ, Kim BJ, Bordet R, Cordonnier C, Dondaine T, Mendyk AM, Lee BC, Yu KH, Lim JS, Kandiah N, Chander RJ, Yatawara C, Lipnicki DM, Sachdev PS; STROKOG Collaboration*. Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study. Stroke. 2020 Jun;51(6):1640-1646. doi: 10.1161/STROKEAHA.119.028428. Epub 2020 May 14. PMID:32404039.

Larrouquere L, Gabin M, Poingt E, Mouffak A, Hlavaty A, Lepelley M, Khouri C, Bellier A, Alexandre J, Bedouch P, Bertoletti L, Bordet R, Bouhanick B, Jonville-Bera AP, Laporte S, Le Jeunne C, Letinier L, Micallef J, Naudet F, Roustit M, Molimard M, Richard V, Cracowski JL. Genesis of an emergency public drug information website by the French Society of Pharmacology and Therapeutics during the COVID-19 pandemic. Fundam Clin Pharmacol. 2020 Jun;34(3):389-396. doi: 10.1111/fcp.12564. PMID: 32394481; PMCID: PMC7273039.

Chan Kwong A, Cassé-Perrot C, Costes-Salon MC, Jouve E, Lanteaume L, Audebert C, Rouby F, Lefebvre MN, Ranjeva JP, Beck A, Deplanque D, Ponchel A, Vervueren C, Truillet R, Babilon C, Auffret A, Richardson JC, Payoux P, Bartrés-Faz D, Blin O, Bordet R, Micallef J; Pharmacog Consortium. An Alzheimer Disease Challenge Model: 24-Hour Sleep Deprivation in Healthy Volunteers, Impact on Working Memory, and Reversal Effect of Pharmacological Intervention: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. J Clin Psychopharmacol. 2020 May/Jun;40(3):222-230. doi: 10.1097/JCP.0000000000001199. PMID: 32332458.

Moreau C, Rolland AS, Pioli E, Li Q, Odou P, Barthelemy C, Lannoy D, Demailly A, Carta N, Deramecourt V, Auger F, Kuchcinski G, Laloux C, Defebvre L, Bordet R, Duce J, Devedjian JC, Bezard E, Fisichella M, Devos D. Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease. Neurobiol Dis. 2020 Jun;139:104846. doi:10.1016/j.nbd.2020.104846. Epub 2020 Mar 20. PMID: 32205254.

Maestrini I, Tagzirt M, Gautier S, Dupont A, Mendyk AM, Susen S, Tailleux A, Vallez E, Staels B, Cordonnier C, Leys D, Bordet R. Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study. Neurology. 2020 Jul 7;95(1):e97-e108. doi: 10.1212/WNL.0000000000009179. Epub 2020 Feb 28. PMID:32111692.

French Association of Addictovigilance Centres, Micallef J, Mallaret M, Lapeyre-Mestre M, Daveluy A, Victorri-Vigneau C, Peyrière H, Debruyne D, DeheulS, Bordet R, Chevallier C, Perault-Pochat MC, Le Boisselier R, Libert F, Chaouachi L, Gillet P. Warning on increased serious health complications related to non-medical use of nitrous oxide. Therapie. 2020 Jan 17:S0040-5957(20)30005-6. French. doi: 10.1016/j.therap.2020.01.002. Epub ahead of print. PMID: 32063400.

Marizzoni M, Ferrari C, Babiloni C, Albani D, Barkhof F, Cavaliere L, Didic M, Forloni G, Fusco F, Galluzzi S, Hensch T, Jovicich J, Marra C, Molinuevo JL, Nobili F, Parnetti L, Payoux P, Ranjeva JP, Ribaldi F, Rolandi E, Rossini PM, Salvatore M, Soricelli A, Tsolaki M, Visser PJ, Wiltfang J, Richardson JC, Bordet R, Blin O, Frisoni GB. CSF cutoffs for MCI due to AD depend on APOEε4 carrier status. Neurobiol Aging. 2020 May;89:55-62. doi: 10.1016/j.neurobiolaging.2019.12.019. Epub 2019 Dec 30. PMID: 32029236.

Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Bertram L, Barkhof F, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Lovestone S. Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. J Alzheimers Dis. 2020;74(1):213-225. doi: 10.3233/JAD-190434. PMID: 31985466; PMCID: PMC7175945.

Stamate D, Kim M, Proitsi P, Westwood S, Baird A, Nevado-Holgado A, Hye A, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, Kate MT, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck E, Engelborghs S, Sleegers K, Bordet R, Ramit L, Kettunen P, Tsolaki M, Verhey F, Alcolea D, Lléo A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Legido-Quigley C. A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimers Dement (N Y). 2019 Dec 18;5:933-938. doi: 10.1016/j.trci.2019.11.001. PMID: 31890857; PMCID:PMC6928349.

Drelon A, Kuchcinski G, Caparros F, Dequatre-Ponchelle N, Moulin S, Cordonnier C, Bordet R, Pruvo JP, Leys D. Remote brain hemorrhage after IV thrombolysis: Role of preexisting lesions. Neurology. 2020 Mar 3;94(9):e961-e967. doi: 10.1212/WNL.0000000000008874. Epub 2019 Dec 27. PMID:31882531.

Lebouvier T, Chen Y, Duriez P, Pasquier F, Bordet R. Antihypertensive agents in Alzheimer's disease: beyond vascular protection. Expert Rev Neurother. 2020 Feb;20(2):175-187. doi: 10.1080/14737175.2020.1708195. Epub 2019 Dec 27. PMID:31869274.

Bordet R, Camu W, De Seze J, Laplaud DA, Ouallet JC, Thouvenot E. Mechanism of action of s1p receptor modulators in multiple sclerosis: The double requirement. Rev Neurol (Paris). 2020 Jan-Feb;176(1-2):100-112. doi:10.1016/j.neurol.2019.02.007. Epub 2019 Nov 19. PMID: 31757428.

Lo JW, Crawford JD, Desmond DW, Godefroy O, Jokinen H, Mahinrad S, Bae HJ, Lim JS, Köhler S, Douven E, Staals J, Chen C, Xu X, Chong EJ, Akinyemi RO, Kalaria RN, Ogunniyi A, Barbay M, Roussel M, Lee BC, Srikanth VK, Moran C, Kandiah N, Chander RJ, Sabayan B, Jukema JW, Melkas S, Erkinjuntti T, Brodaty H, Bordet R, Bombois S, Hénon H, Lipnicki DM, Kochan NA, Sachdev PS; Stroke and Cognition (STROKOG) Collaboration. Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups. Neurology. 2019 Dec 10;93(24):e2257-e2271. doi: 10.1212/WNL.0000000000008612. Epub 2019 Nov 11. PMID: 31712368; PMCID: PMC6937495.

Betrouni N, Yasmina M, Bombois S, Pétrault M, Dondaine T, Lachaud C, Laloux C, Mendyk AM, Henon H, Bordet R. Texture Features of Magnetic Resonance Images: an Early Marker of Post-stroke Cognitive Impairment. Transl Stroke Res. 2020 Aug;11(4):643-652. doi: 10.1007/s12975-019-00746-3. Epub 2019 Nov 1. PMID:31677092.