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Publications

2020

Ando K, De Decker R, Vergara C, Yilmaz Z, Mansour S, Suain V, Sleegers K, de Fisenne MA, Houben S, Potier MC, Duyckaerts C, Watanabe T, Buée L, Leroy K, Brion JP (2020) Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta Neuropathol, 139:773–789 doi:10.1007/s00401-020-02125-x

Boue-Grabot E, Blum D, Ceruti S. Editorial: Purinergic Signaling in Health and Disease. Front Cell Neurosci. 2020 Feb 4;14:15

Colin M, Dujardin S, Schraen-Maschke S, Meno-Tetang G, Duyckaerts C, Courade JP, Buée L (2020) Exploring anti-tau immunotherapy within the hypothesis of the prion-like propagation. Acta Neuropathol, 139: 3-25

Duriez P, Eddarkaoui S, Blum D, Gorwood P, Tolle V, Viltart O. Does physical activity associated with chronic food restriction alleviate anxiety like behaviour, in female mice? Horm Behav. 2020 Jun 13:104807

Hector A, McAnulty C, Piché-Lemieux ME, Alves-Pires C, Buée-Scherrer V, Buée L*, Brouillette J* (2020) Tau hyperphosphorylation induced by the anesthetic agent ketamine/xylazine involved the calmodulin-dependent protein kinase II. FASEB J, 34(2):2968–2977

Gomez-Murcia V, Sandau U, Ferry B, Parrot S, Laurent C, Basquin M,  Buée L, Boison D, Blum D (2020) Hyperexcitability and seizures in the THY-Tau22 mouse model of Tauopathy. Neurobiol Aging, 94:265-270.

Homa M, Loyens A, Eddarkaoui S, Faivre E, Deramecourt V, Maurage CA, Buée L, Huin V, Sablonnière B (2020) The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals. Cerebellum 19(3):358‐369. doi:10.1007/s12311-020-01112-y

Montembeault M, Sayah S, Rinaldi D, et al. Cognitive inhibition impairments in presymptomatic C9orf72 carriers. J Neurol Neurosurg Psychiatry. 2020;91(4):366-372. doi:10.1136/jnnp-2019-322242

Nebie O, Barro L, Wu YW, Knutson F, Buée L, Devos D, Peng CW, Blum D, Burnouf T (2019) Heat-treated human platelet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro. Platelets, in press

Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, Do KQ, Halliez S, Bezzi P, Buee L, Leuba G, Colin M, Toni N, Déglon N. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease. Nature Neurosci, in press.

Sellami L, Rucheton B, Ben Younes I, et al. Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience. Neurobiol Aging. 2020;91:167.e1-167.e9.

Sierksma A, Lu A, Salta E, Mancuso R, Zoco J, Blum D, Buée L, De Strooper B, Fiers M (2020) Novel Alzheimer risk genes determine the microglia response to amyloid ß but not to TAU pathology. EMBO Mol Med, in press.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, CE, Pimentel J, Schiffmann SN, Buée L, Outeiro TF, Bader M, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV (2020) Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors. Mol Psychiatr, in press.

Verelst J, Geukens N, Eddarkaoui S, Vliegen D, De Smidt E, Rosseels J, Franssens V, Molenberghs S, Francois C, Stoops E, Bjerke M, Engelborghs S, Laghmouchi M, Carmans S, Buée L, Vanmechelen E, Winderickx J, Thomas D (2020) A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms. Front Mol Biosci, 7:48. doi:10.3389/fmolb.2020.00048

Zheng J, Akbari M, Schirmer C, Reynaert ML, Loyens A, Lefebvre B, Buée L, Croteau DL, Galas MC, Bohr VA (2020) Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta Neuropathol Commun, 8(1):25. doi:10.1186/s40478-020-00896-8

2019

Albert M, Mairet-Coello G, Danis C, Lieger S, Caillierez R, Carrier S, Skrobala E, Landrieu I, Michel A, Schmitt M, Citron M, Downey P, Courade JP, Buée L*, Colin M* (2019) Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody. Brain, 142(6):1736-1750

Bernard C, Zappettini S, Faivre E, Ghestem A, Carrier S, Buee L, Blum D, Esclapez M (2019) Caffeine consumption during pregnancy accelerates the development of cognitive deficits in offspring in a model of tauopathy. Frontiers Cell Neurosci, 13: 438.

Blommaert D, Sergeant N, Delehedde M, et al. Expression, localization, and concentration of A-kinase anchor protein 4 (AKAP4) and its precursor (proAKAP4) in equine semen: Promising marker correlated to the total and progressive motility in thawed spermatozoa. Theriogenology. 2019;131:52-60.

Bossenmeyer-Pourié C, Smith AD, Lehmann S, et al. N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia. J Pathol. 2019;248(3):291-303.

Carvalho K, Faivre E, Pietrowski MJ, Marques X, Gomez-Murcia V, Deleau A, Huin V, Hansen JN, Kozlov S, Danis C, Temido-Ferreira M, Coelho JE, Mériaux C, Eddarkaoui S, Le Gras S, Dumoulin M Cellai L, NeuroCEB Brain Bank, Landrieu I, Chern Y, Hamdane M, Buée L, Boutillier AL, Levi S, Halle A, Lopes LV, Blum D (2019) Exacerbation of C1q dysregulation, synaptic loss and memory deficits in Tau pathology linked to neuronal adenosine A2Areceptors. Brain, 142(11): 3636-54

Chaalal A, Poirier R, Blum D, Laroche S, Enderlin V. Thyroid Hormone Supplementation Restores Spatial Memory, Hippocampal Markers of Neuroinflammation, Plasticity-Related Signaling Molecules, and β-Amyloid Peptide Load in Hypothyroid Rats. Mol Neurobiol. 2019 Jan;56(1):722-735

Corvol JC, Buée L (2019) A new step towards targeting tau. Lancet Neurol, 18:517-8.

Domise M, Sauvé F, Didier S, Caillerez R, Bégard S, Carrier S, Colin M, Marinangeli C, Buee L, Vingtdeux V (2019) Neuronal AMP-activated protein kinase (AMPK) hyper-activation induces synaptic loss by an autophagy mediated process. Cell Death Dis, 10:221

Dupré E, Danis C, Arrial A, Cantrelle FX, Merzougui H, Hanoulle X, Colin M, Rain JC, Buée L*, Landrieu I* (2019) Single chain antibody fragments as new tools for studying the neuronal Tau protein physiopathology. ACS Chemical Neurosci, 10(9):3997-4006

Faldini E, Ahmed T, Buee L, Blum D, Balschun D (2019) Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models. Acta Neuropathol Comm, 7:202 

Fichou Y, Al-Hilaly YK, François Devred F, Smet-Nocca C Tsvetkov PO, Verelst J, Winderickx J, Geukens N, Vanmechelen E, Perrotin A, Serpell L, Hanseeuw B, Medina M, Buée L*, Landrieu I* (2019) The elusive Tau Molecular structures: Can we translate the recent breakthroughs into new targets for intervention? Acta Neuropathol Commun, 7:31

Gary C, Lam S, Herard AS, Koch JE, Petit F, Gipchtein P, Sawiak SJ, Caillierez R, Eddarkaoui S, Colin M, Aujard F, Deslys JP, French neuropathology network, Brouillet E, Buée L, Comoy EE, Pifferi F, Picq JL, Dhenain M (2019) Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta Neuropathol Commun, 7(1)126.

Houben S, Leroy K, Ando K, Yilmaz Z, Widomski C, Buée L, Brion JP (2019) Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiol Dis, 127:131-141  https://pubmed.ncbi.nlm.nih.gov/30818066/

Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus R, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock D, Blum D, Latz E, Buee L, Heneka M (2019) NLRP3 inflammasome activation drives tau pathology. Nature, 575(7784): 669-673

Jadhav S, Avila J, Schöll M, Kovacs G, Kövari E, Skrabana R, Evans L, Kontsekova E, Malawska B, de Silva R, Buée L*, Zilka N* (2019) A walk through tau therapeutic strategies. Acta Neuropathol Commun, 7: 22.

Leboucher A, Ahmed T, Caron E, Tailleux A, Raison S, Joly Amado A, Marciniak E, Carvalho K, Hamdane M, Bantubungi K, Lancel S, Eddarkaoui S, Caillierez R, Vallez E, Staels B, Vieau D, Balschun D, Buée L*, Blum D* (2019) Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model. Neurobiol Dis, 125 :14-22.

Lemaire Q, Raffo-Romero A, Arab T, Van Camp C, Drago F, Forte S, Gimeno JP, Begard S, Colin M, Vizioli J, Sautiere PE, Salzet M, Lefebvre C. Isolation of microglia-derived extracellular vesicles: towards miRNA signatures and neuroprotection. J Nanobiotechnology. 2019 Dec 4;17(1):119

Loera-Valencia R, Cedazo-Minguez A, Kenigsberg PA, Page G, Duarte A, Giusti P, Zusso M, Robert P, Frisoni G, Cattaneo A, Zille M, Boltze J, Cartier N, Buee L, Johansson G, Winblad B (2019) Current and emerging avenues for Alzheimer’s disease drug targets. J Intern Med, 286(4):398-437

Nebie O, Devos D, Vingtdeux V, Barro L, Devedjian JC, Jonneaux A, Chou ML, Bordet R, Buée L, Knutson F, Blum D, Burnouf T (2019) The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates. J Biomed Sci, 26(1):89. doi: 10.1186/s12929-019-0579-9

Nixon B, Bernstein IR, Cafe SL, Delehedde M, Sergeant N et al. A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells. Front Cell Dev Biol. 2019;7:319.

Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Le Fur N, Evrard C, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Hamdane M, Buee L, Melnyk P (2019) New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer’s disease. Neurobiol Dis, 129: 217-33.

Shrivastava AN, Redeker V, Pieri L, Bousset L, Renner M, Madiona K, Mailhes-Hamon C, Coens A, Buée L, Hantraye P, Triller A, Melki R (2019) Clustering of tau fibrils impairs the synaptic composition of 3-Na+/K+-ATPase and AMPA receptors. EMBO J, 38, e99871

Wen J, Zhang H, Alexander DC, et al. Neurite density is reduced in the presymptomatic phase of C9orf72 disease. J Neurol Neurosurg Psychiatry. 2019;90(4):387-394.

2018

Benhelli-Mokrani H, Chauderlier A, Mansuroglu Z, Albaud B, Gentien D, Sommer S, Schirmer C, Laqueuvre L, Josse T, Buee L, Lefebvre B, Galas MC, Soues S, Bonnefoy E (2018) Genome-wide identification of neuronal DNA regions bound by Tau protein under physiological and stress conditions. Nucleic Acids Res, 46(21):11405-11422

Bergeron D, Gorno-Tempini ML, Rabinovici GD, et al. Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. Ann Neurol. 2018;84(5):729-740.

Blum D, Chern Y, Domenici MR, Buee L, Lin CY, Rea W, Ferre S, Popoli P. The role of adenosine tone and adenosine receptors in Huntington’s disease. J Caffeine and Adenosine Res, 8: 43-58.

Cellai L, Carvalho K, Faivre E, Deleau A, Vieau D, Buée L, Blum D, Meriaux C, Gomez Murcia V (2018) The adenosinergic signaling: a complex but promising therapeutic target for Alzheimer’s disease. Frontiers Neurosci, 12: 520

Chatterjee S, Cassel R, Schneider-Anthony A, Merienne K, Cosquer B, Tzeplaeff L, Halder Sinha S, Kumar M, Chaturbedy P, Eswaramoorthy M, Le Gras S, Keime C, Bousiges O, Dutar P, Petsophonsakul P, Rampon C, Cassel JC, Buée L, Blum D, Kundu TK, Boutillier AL (2018) Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator. EMBO Mol Med, 10(11). pii: e8587.

Chauderlier A, Gilles M, Spolcova A, Caillierez R, Chwastyniak M, Kress M, Drobecq H, Bonnefoy E, Pinet F, Weil D, Buee L, Galas MC, Lefebvre B (2018) Tau/DDX6 interaction increases microRNA activity. BBA Gene Regulatory Mechanisms, 8: 762-72.

d’Orange M, Aurégan G, Cheramy D, Gaudin-Guérif M, Lieger S, Guillermier M, Stimmer L, Joséphine C, Hérard AS, Gaillard MC, Petit F, Kiesslings MC, Schmitz C, Colin M, Buee L, Panayi F, Diguet E, Brouillet E, Hantraye P, Bemelmans AP, Cambon K (2018) Potentiating tangle formation reduces acute toxicity of soluble Tau species in the rat. Brain, 141(2):535-549.

Dujardin S, Lachaud C, Caillierez R, Bégard S, Carrier S, Lieger S, Gonzales JA, Moore BD, Deramecourt V, Deglon N, Maurage CA, Frosch MP, Hyman BT, Colin M, Buée L (2018)  Different Tau species lead to heterogeneous Tau pathology propagation and misfolding. Acta Neuropathol Commun, 6:132

Duron E, Vidal JS, Grousselle D, Gabelle A, Lehmann S, Buée L, Allinquant B, Schraen-Maschke S, Baret C, Rigaud AS, Hanon O, Epelbaum J (2018) Somatostatin and neuropeptide Y in cerebrospinal fluid: correlations with amyloid peptides Aß1-42, and tau proteins in elderly patients with mild cognitive impairment. Frontiers Aging Neurosci, 10 : 297.

Faivre E, Coelho JE, Zornbach K, Malik E, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Muller CE, Halle A, Buée L, Lopes LV, Blum D (2018) Beneficial effect of an adenosine A_2AR antagonist in the APPswe/PS1dE9 mouse model of Alzheimer’s Disease. Frontiers Mol Neurosci, 11:235.n

Gay M, Evrard C, Descamps F, Carato P, Renault N, Coevoet M, Eddarkaoui S, Baud C, Larchanche PE, Buee L, El Bakali J, Vingtdeux V, Sergeant N, Melnyk P (2018) Biaryl-Based Amyloid Precursor Protein Modulators: Toward a New Profile of Indirect A Phenotypic Approach to the Discovery of Compounds that Promote Non-Amyloidogenic Processing of the Amyloid Precursor Protein: Toward a New Profile of Indirect β-Secretase Inhibitors. Eur J Med Chem, 159: 104-125.

Giralt A, de Pins B, Cifuentes-Díaz C, et al. PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease. Exp Neurol. 2018;307:62-73

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Bif√©ri MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C. ß-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models. Biol Psychiatry. 2018 Mar 1;83(5):416-427

Gratuze M, Joly-Amado A, Vieau D, Buée L, Blum D (2018) Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ? Neuroendocrinology, 107: 181-95

Hanon O, Vidal JS, Lehmann S, Bombois S, Allinquant B, Tréluyer JM, Gelé P, Delmaire C, Blanc F, Buée L, Touchon J, Hugon J, Vellas B, Galbrun E, Benetos A, Berrut G, Paillaud E, Wallon D, Castelnovo G, Volpe–Gillot L, Paccalin M, Robert PH, Godefroy O, Dantoine T, Camus V, Belmin J, Vandel P, Novella JL, Duron E, Rigaud AS, Schraen S*, Gabelle* on behalf of the BALTAZAR study group (2018) Plasma amyloid levels within the Alzheimer’s process and correlations with central biomarkers. Alzheimers & Dementia, 14:858-68

Jumeau F, Sigala J, Dossou-Gbete F, Frimat K, Barbotin AL, Buée L, Behal H, Sergeant N, Mitchell V (2018) A-kinase anchor protein 4 precursor (pro-AKAP4) in human sperm. Andrology, 6(6):854-859

Laurent C, Buée L, Blum D (2018) Tau and neuroinflammation: what impact for Alzheimer’s disease and Tauopathies. Biomed J, 41: 21-33

Lee CC, Chang CP, Lin CJ, Lai HL, Kao YH, Cheng HC, Chen HM, Liao YP, Faivre E, Buée L, Blum D, Fang JM, Chern Y (2018) Adenosine augmentation evoked by an ENT1 inhibitor improves memory impairment and neuronal plasticity in the APP/PS1 mouse model of Alzheimer’s disease. Mol Neurobiol, 55(12):8936-8952

Marinangeli C, Didier S, Ahmed T, Caillerez R, Domise M, Laloux C, Bégard S, Carrier S, Colin M, Marchetti P, Ghesquière B, Balschun D, Buée L, Kluza J, Vingtdeux V (2018) AMP-activated protein kinase is essential for the maintenance of energy levels during synaptic activation. iScience, 9: 1-13.

Popelova A, Prazienkova V, Neprasova B, Kasperova BJ, Hruba L, Holubova M, Zemenova J, Blum D, Zelezna B, Galas MC, Kunes J, Maletinska L. Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy. J Alzheimers Dis. 2018;62(4):1725-1736

Roudil J, Deramecourt V, Dufournet B, et al. Influence of Lewy Pathology on Alzheimer's Disease Phenotype: A Retrospective Clinico-Pathological Study. J Alzheimers Dis. 2018;63(4):1317-1323

Sierksma A, Lu A, Salta E, Vanden Eynden E, Callaerts-Vegh Z, D'Hooge R, Blum D, Buee L, Fiers M, De Strooper B (2018) Deregulation of neuronal miRNAs induced by either amyloid-β or TAU pathology. Mol Neurogener, 13(1):54.

Vandenbussche C, Van der Hauwaert C, Dewaeles E, Franczak J, Hennino MF, Gnemmi V, Savary G, Tavernier Q, Nottet N, Paquet A, Perrais M, Blum D, Mari B, Pottier N, Glowacki F, Cauffiez C. Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation. Arch Toxicol. 2018 Apr;92(4):1539-1550

Vercruysse O, Paquet C, Gabelle A, Delbeuck X, Blanc F, Wallon D, Dumurgier J, Magnin E, Martinaud O, Jung B, Bousiges O, Lehmann S, Delaby C, Quillard-Murain M, Peoc'h K, Laplanche JL, Bouaziz-Amar E, Hannequin D, Sablonniere B, Buee L, Hugon J, Schraen S, Pasquier F, Bombois S (2018) Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF biomarkers. Curr Alz Res, 15: 691-700

2017

Dourlen P, Fernandez-Gomez F, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Dermaut B, Lambert JC (2017) Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Mol Psychiatr, 22(6):874-883. doi: 10.1038/mp.2016.59

Duroux R, Renault N, Cuelho JE, Agouridas L, Blum D, Lopes LV, Melnyk P, Yous S. Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2 receptor. J Enzyme Inhib Med Chem. 2017 Dec;32(1):850-864

Gibier JB, Hemon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, Van Seuningen I, Glowacki F, Cauffiez C, Blum D, Copin MC, Perrais M, Gnemmi V. Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1336-1349

Huin V, Buée L, Behal H, Labreuche J, Sablonnière B, Dhaenens CM (2017) Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer’s disease and progressive supranuclear palsy brains. Sci Rep, 7(1):12589. doi: 10.1038/s41598-017-12955-7

Jumeau F, Chalmel F, Fernandez-Gomez FJ, Carpentier C, Obriot H, Tardivel M, Caillet-Boudin ML, Rigot JM, Rives N, Buée L, Sergeant N, Mitchell V (2017) Defining the human sperm microtubulome: an integrated genomics approach. Biol Reprod, 96(1) 93-106. doi: 10.1095/biolreprod.116.143479

Laurent C, Dorothée G, Hunot S, Martin E, Monnet Y, Duchamp M, Duong Y, Légeron FP, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N, Sazdovitch V, Schraen-Maschke S, Delarasse C, Buée L*, Blum D* (2017) Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of Tauopathy. Brain, 140(Pt 1):184-200. doi: 10.1093/brain/aww270

Lebouvier T, Pasquier F, Buée L (2017) Update on Tauopathies. Curr Op Neurol, 30(6):589-598

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L*, Blum D* (2017) Tau deletion promotes brain insulin resistance. J Exp Med, 214(8):2257-2269. doi: 10.1084/jem.20161731

Moulin S, Leys D, Schraen-Maschke S, Bombois S, Mendyk AM, Muhr-Tailleux A, Cordonnier C, Buee L, Pasquier F, Bordet R (2017) Aβ1-40 and Aβ1-42 plasmatic levels in Stroke: Influence of pre-existing cognitive status and stroke characteristics. Curr Alzheimer Res 14(6): 686-694

Mudher A, Brion JP, Avila J, Medina M, Buée L (2017) EuroTau meeting: Towing scientists to Tau without tautology. Acta Neuropathol Commun, 5: 90

Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Alvavi Naini SM, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP (2017) What is the evidence that Tau pathology spreads through a prion-like propagation ? Acta Neuropathol Comm, 5: 99

Paban V, Loriod B, Villard C, Buée L, Blum D, Pietropaolo S, Cho YH, Gory-Faure S, Mansour E, Gharbi A, Alescio-Lautier B (2017) Omics analysis of mouse brain models of human diseases. Gene, 600:90-100. doi: 10.1016/j.gene.2016.11.022

Shelkovnikova TA, Dimasi P, Kukharsky M, An H, Quintiero A, Schirmer C, Buée L, Galas MC, Buchman VL (2017) Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly. Cell Death Dis, 8(5):e2788. doi: 10.1038/cddis.2017.199

Šimić G, Leko MB, Wray S, Harrington C, Delalle I, Jovanov-Milošević N, Bažadona D, Buée L, Silva R, Giovanni GD, Wischik C, Hof PR (2017) Monoaminergic Neuropathology in Alzheimer's disease. Prog Neurobiol, 151 : 101-138

Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, Blum D, Sayas CL, Mandelkow EM, Mandelkow E, Spillantini MG, Sousa N, Avila J, Medina M, Mudher A, Buee L (2017) Atypical, non-standard functions of the microtubule-associated Tau protein. Acta Neuropathol Comm, 5: 91

Vanden Dries V, Stygelbout V, Pierrot N, Yilmaz Z, Suain V, De Decker R, Buée L, Octave JN, Brion JP, Leroy K (2017) Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model. Neurobiol Aging, 55:202-212

Brevets

Brevets déposés

• EP17210486.1 Cauffiez C, Perrais M, Blum D. KIT-OF-PARTS COMPRISING A NEPHROTOXIC CHEMOTHERAPEUTIC DRUG AND A SELECTIVE A2A ADENOSINE RECEPTOR ANTAGONIST. December 22, 2017.
• EP17305355.4 Hamdane M, Derisbourg M, Leghay C, Chiappetta G, Verdier Y, Vinh J, Blum D, Buée L. New Tau species. March 28, 2017.

Brevets acceptés

• WO2015068075  –  Buée L, Colin M, Hantraye P, Aron Badin R, Dujardin S, Bemelmans A, Brouillet E. DETECTION OF TAU.
• WO2014096321 – Buée L, Troquier L, Lassalle P. ANTIBODIES SPECIFIC TO TAU PHOSPHORYLATED AT SERINE 422 AND USES FOR THE TREATMENT AND DIAGNOSIS OF TAUOPATHIES.

Brevets licenciés

• US20160356785 Sergeant N, Mitchell V, Jumeau F, Sigala J. Methods for determining human sperm quality. Licence exclusive à 4BioDx.
• WO2016146655 : Sergeant N, Melnyk P, Buée L. Novel 1,4-bis(3-aminopropyl)piperazine derivatives and its use. 16 mars 2015 (Accord de licence en discussion avec la société Alzprotect).
• WO2015032842 : Sergeant N, Mitchell V, Jumeau F, Sigala J. Méthodes de détermination de la qualité du sperme humain. Licence exclusive à 4BioDx.
• WO2014102339 : Barrier M, Buée L, Burlet S, Delacourte A, Estrella C, Melnyk P, Sergeant N, Verwaerde P. Sulfate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine. AlzProtecT – phase I terminée en 2015.
• W02006051489 : Melnyk Patricia, Sergeant Nicolas, Buée Luc, Delacourte André, Inserm, Université de Lille II, « Use of 1, 4-bis(3 aminopropyl)piperazine derivatives in therapy ». http://www.wipo.int/pctdb/en/wo.jsp?WO=2006051489 Licensed to AlzProtecT.
  Molécule actuellement en essai clinique chez l’homme – phase I terminée en 2015.

Thèses

Thèses en cours

• DENECHAUD Marine (D1 en 2018 – dir. thèse : Marie-Christine GALAS)
• GUEDJDAL Sarah (D1 en 2017 – dir. thèse : Malika HAMDANE)
• NEBIE Ouada (D1 en 2017 – dir. thèse : David BLUM et Thierry BURNOUF)
• LEROUX Elodie (D1 en 2018 – dir. thèse : Morvane COLIN)
• LEROY Melanie (D1 en 2018 – dir. thèse : Vincent DERAMECOURT)
• PERBET Romain (D1 en 2017 – dir. thèse : Morvane COLIN)
• RICO Thomas (D1 en 2018 – dir. thèse : Bruno LEFEBVRE)
• SOUSA Cristiano (D1 en 2018 – dir. thèse : Malika HAMDANE et Karen VANHOORELBEKE)
• TAUTOU Marie (D1 en 2018 – dir. thèse : Nicolas SERGEANT)
• ZEJNELI Orgeta (D1 en 2018 – dir. thèse : Luc BUEE et Isabelle LANDRIEU)

Thèses soutenues depuis 2017

• HOMA Mégane (Sout. le 14/01/2020) sous la direction de Bernard Sablonnière
• CARVALHO Kevin (sout.le 14/10/2019 sous la direction de David Blum) (titre/résumés)
• ERDUAL Edmone (sout.le 05/11/2019sous ladirection de Nicolas Pottier) (titre/résumés)
• ALBERT Marie (sout. le 10/12/2018 sous la direction de Morvane COLIN) (titre/résumés)
• DANIS Clément (soutenance le 14/12/2018 sous la direction de Isabelle LANDRIEU et Luc BUEE) (titre/résumés)
• DOMISE Manon (soutenance le 17/12/2018 sous la direction de Valerie VINGTDEUX) (titre/résumés)
• EVRARD Caroline (sout. le 20/11/2018 sous la direction de Nicolas SERGEANT) (titre/résumés)
• GILLES Melissa (sout. le 13/11/2018 sous la direction de Bruno LEFEBVRE) (titre/résumés)
• TARDIVEL-SAFI Meryem (sout. le 6/12/2017 sous la direction de : Morvane COLIN) (titre/résumés)
• LEGHAY Coline (sout. le 19/09/2017 sous la direction de : Malika HAMDANE (titre/résumés)