Degenerative and vascular cognitive discorders


This team, made up of clinical and pre-clinical researchers, is multidisciplinary. It is located at the interface between neurology, pharmacology and imaging. The research project is focused on the translational, transnosographic and multimodal study of cognitive disorders associated with degenerative processes or neurovascular lesions, starting from the observation that the mechanisms are entangled.



The goal of the neurophysiology project team is to develop and use the neurophysiological tools (high-resolution electroencephalogram, non-invasive brain stimulation, motion analysis) necessary for the understanding and management of neurologically expressed diseases. More fundamental aspects aiming to better understand brain function and to develop relevant markers of a pathophysiological process are also developed. The team is particularly interested in motor control and its interactions with cognitive impairment, whether in aging (impact on falls) or in pathologies of the basal ganglia (Parkinson's disease), in post-stroke, in dementias, epilepsy or in neuro-muscular diseases. A final approach concerns decisional medicine. The aim is to exploit the physiological markers identified in cohort studies to facilitate their use in routine clinical practice. The work is based on the use of machine learning and big data approaches to build decision models going to the individual patient level and optimally combining the different markers.


Team: Nacim Betrouni et Philippe Derambure


  • Development of numerous collaborations in recent year
    • at the Lille campus (Cristal laboratory, François Cabestaing, development of brain-machine interfaces, Scalab, Cedrick Bonnet, posturographic aspects; Ali Amad and Arnaud Leroy, neuromodulation and behavioral disorders),
    • at the regional level (ULCO, Hervé Devanne: modulation of cortical activity, plasticity and consequences on motor control)
    • at a national level (University of Bordeaux, Prof. Dominique Guehl, Prof. Fabrice Wendling and Mahmoud Hassan (LTSI UMR Inserm Université de Rennes))
    • at an international level (University of Kiel, Christian Schlenstedt, University of Nijmegen, Bas Bloem, Claudio Babiloni (Department of Physiology and Pharmacology, University of Sapienza, Italy)…
  • Implementation over the past 3 years of methods for analyzing functional connectivity in EEG
  • Development of operational routines within the team to accommodate students with little training in signal processing (source analysis, evoked potentials, time-frequency analysis, connectivity)
  • Technical platform allowing communication of tools (stimulation PC allowing administration of cognitive tests, High resolution EEG, movement analysis system, neuromodulation systems, etc.)



Allali G, Blumen H, Devanne H, Pirondini E, Delval A, Van De Ville D. Brain imaging of locomotion in neurological conditions. Neurophysiol Clin 2018;48:337–59.

Allart E, Delval A, Caux-Dedeystere A, Labreuche J, Viard R, Lopes R, et al. Parietomotor connectivity in the contralesional hemisphere after stroke: A paired-pulse TMS study. Clin Neurophysiol 2017;128:707–15.

Allart E, Devanne H, Delval A. Contribution of transcranial magnetic stimulation in assessing parietofrontal connectivity during gesture production in healthy individuals and brain-injured patients. Neurophysiol Clin 2019;49:115–23.

Allart E, Viard R, Lopes R, Devanne H, Delval A. Influence of Motor Deficiency and Spatial Neglect on the Contralesional Posterior Parietal Cortex Functional and Structural Connectivity in Stroke Patients. Brain Topogr 2020;33:176–90.

Barthel C, van Helvert M, Haan R, Janssen A, Delval A, de Vries N, et al. Visual cueing using laser shoes reduces freezing of gait in Parkinson’’s patients at home. Mov Disord 2018a;33:1664–5.

Barthel C, Nonnekes J, van Helvert M, Haan R, Janssen A, Delval A, et al. The laser shoes: A new ambulatory device to alleviate freezing of gait in Parkinson disease. Neurology 2018b;90:e164–71.

Bayot M, Delval A, Moreau C, Defebvre L, Hansen C, Maetzler W, et al. Initial center of pressure position prior to anticipatory postural adjustments during gait initiation in people with Parkinson’’s disease with freezing of gait. Parkinsonism Relat Disord 2021;84:8–14.

Bayot M, Dujardin K, Dissaux L, Tard C, Defebvre L, Bonnet C, et al. Can dual-task paradigms predict Falls better than single task? - A systematic literature review. Neurophysiol Clin 2020;50:401–40.

Bayot M, Dujardin K, Tard C, Defebvre L, Bonnet C, Allart E, et al. The interaction between cognition and motor control: A theoretical framework for dual-task interference effects on posture, gait initiation, gait and turning. Neurophysiol Clin 2018;48:361–75.

Besson P, Carrière N, Bandt S, Tommasi M, Leclerc X, Derambure P, et al. Whole-Brain High-Resolution Structural Connectome: Inter-Subject Validation and Application to the Anatomical Segmentation of the Striatum. Brain Topogr 2017;30:291–302.

Betrouni N, Delval A, Chaton L, Defebvre L, Duits A, Moonen A, et al. Electroencephalography-based machine learning for cognitive profiling in Parkinson’’s disease: Preliminary results. Mov Disord 2019;34:210–7.

Bocquillon P, Charley-Monaca C, Houdayer E, Marques A, Kwiatkowski A, Derambure P, et al. Reduced afferent-induced facilitation of primary motor cortex excitability in restless legs syndrome. Sleep Med 2017;30:31–5.

Bonnet C, Delval A, Singh T, Defebvre L. Parkinson’’s disease-related changes in the behavioural synergy between eye movements and postural movements. Eur J Neurosci 2021a;54:5161–72.

Bonnet C, Delval A, Singh T, Kechabia Y, Defebvre L. New insight into Parkinson’’s disease-related impairment of the automatic control of upright stance. Eur J Neurosci 2020;52:4851–62.

Bonnet C, Delval A, Szaffarczyk S, Defebvre L. Levodopa has primarily negative influences on postural control in patients with Parkinson’’s disease. Behav Brain Res 2017;331:67–75.

Bonnet C, Dubrulle D, Barela J, Defebvre L, Delval A. Optimization of postural control in precise gaze shifts and laser pointing. Hum Mov Sci 2021b;79:102853.

Braquet A, Bayot M, Tard C, Defebvre L, Derambure P, Dujardin K, et al. A new paradigm to study the influence of attentional load on cortical activity for motor preparation of step initiation. Exp Brain Res 2020;238:643–56.

Caux-Dedeystère A, Allart E, Morel P, Kreisler A, Derambure P, Devanne H. Late cortical disinhibition in focal hand dystonia. Eur J Neurosci 2021;54:4712–20.

Del Percio C, Derambure P, Noce G, Lizio R, Bartrés-Faz D, Blin O, et al. Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults. Clin Neurophysiol 2019;130:1488–98.

Delval A, Bayot M, Defebvre L, Dujardin K. Cortical Oscillations during Gait: Wouldn’’t Walking be so Automatic? Brain Sci 2020;10.

Delval A, Bayot M, Lapoulvereyrie R, Defebvre L, Vermersch P, Tard C. Role of the peripheral nervous system for an appropriate postural preparation during gait initiation in patients with a chronic inflammatory demyelinating polyneuropathy: A pilot study. Gait Posture 2021a;90:29–35.

Delval A, Betrouni N, Tard C, Devos D, Dujardin K, Defebvre L, et al. Do kinematic gait parameters help to discriminate between fallers and non-fallers with Parkinson’’s disease? Clin Neurophysiol 2021b;132:536–41.

Delval A, Braquet A, Dirhoussi N, Bayot M, Derambure P, Defebvre L, et al. Motor Preparation of Step Initiation: Error-related Cortical Oscillations. Neuroscience 2018;393:12–23.

Delval A, Defebvre L, Tard C. Freezing during tapping tasks in patients with advanced Parkinson’’s disease and freezing of gait. PLoS One 2017;12:e0181973.

Derambure P, Lefaucheur J. Clinical neurophysiology: The quest to understand motor and postural control. Neurophysiol Clin 2019;49:89–90.

Hassan M, Chaton L, Benquet P, Delval A, Leroy C, Plomhause L, et al. Functional connectivity disruptions correlate with cognitive phenotypes in Parkinson’’s disease. Neuroimage Clin 2017;14:591–601.

Lacan L, Betrouni N, Lamblin M, Chaton L, Delval A, Bourriez J, et al. Quantitative approach to early neonatal EEG visual analysis in hypoxic-ischemic encephalopathy severity: Bridging the gap between eyes and machine. Neurophysiol Clin 2021;51:121–31.

Leroy A, Beigné M, Petyt G, Derambure P, Vaiva G, Amad A. Psychogenic non-epileptic seizures treated with guided transcranial direct current stimulation: A case report. Brain Stimul 2019;12:794–6.

Leroy C, Bourriez J, Dujardin K, Molaee-Ardekani B, Babiloni C, Deplanque D, et al. A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers. Clin Neurophysiol 2019;130:863–75.

Niguet J, Tortuyaux R, Garcia B, Jourdain M, Chaton L, Préau S, et al. Neurophysiological findings and their prognostic value in critical COVID-19 patients: An observational study. Clin Neurophysiol 2021;132:1009–17.

Viseux F, Delval A, Defebvre L, Simoneau M. Postural instability in Parkinson’’s disease: Review and bottom-up rehabilitative approaches. Neurophysiol Clin 2020;50:479–87.